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NOXA1 Knockout Cell Lines

Gene: NOXA1

Official Full Name: NADPH oxidase activator 1provided by HGNC

Gene Summary: This gene encodes a protein which activates NADPH oxidases, enzymes which catalyze a reaction generating reactive oxygen species. The encoded protein contains four N-terminal tetratricopeptide domains and a C-terminal Src homology 3 domain. Interaction between the encoded protein and proteins in the oxidase regulatory complex occur via the tetratricopeptide domains. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO03432 NOXA1 Knockout cell line (HEK293) Human NOXA1 1:3~1:6 Negative Online Inquiry

Background

NOXA1 Gene Knockout Cell Lines are specialized cell models engineered to lack the NOXA1 gene, which encodes a protein critical to the function of the NADPH oxidase complex. This gene knockout results in the loss of specific reactive oxygen species (ROS) production, thereby providing a unique platform for investigating the roles of oxidative stress in cellular processes such as inflammation, apoptosis, and pathogen defense.

The primary function of these cell lines is to facilitate research into the dual roles of NOXA1 in both normal physiology and disease states. By eliminating NOXA1 expression, researchers can assess downstream signaling pathways and determine how the absence of this gene influences oxidative stress responses. This understanding is vital in cancer research, cardiovascular studies, and the exploration of neurodegenerative diseases, as NOXA1 is implicated in various pathological conditions.

Scientifically, the NOXA1 Gene Knockout Cell Lines offer unique insights into redox biology, enabling researchers to dissect the complexities of cellular signaling mediated by ROS. In a clinical setting, findings derived from these models may pave the way for novel therapeutic strategies aimed at modulating oxidative stress, particularly in diseases where NOXA1 plays a pivotal role.

Compared to alternative models, our NOXA1 Gene Knockout Cell Lines provide enhanced specificity and reproducibility, allowing for clear assessment of the functional implications of NOXA1 ablation. Their robust design ensures consistent performance across experiments, significantly reducing variability and increasing the reliability of experimental outcomes.

The value of our NOXA1 Gene Knockout Cell Lines to researchers and clinicians cannot be understated: they represent an essential tool in understanding complex biological processes, aiding in the development of targeted therapies. This innovative product is backed by our company's extensive expertise in genetic engineering and cell biology, positioning us as a leader in the provision of high-quality biological products that meet the evolving needs of the scientific community.

Please note that all services are for research use only. Not intended for any clinical use.

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