Gene: NOS3
Official Full Name: nitric oxide synthase 3provided by HGNC
Gene Summary: Nitric oxide is a reactive free radical which acts as a biologic mediator in several processes, including neurotransmission and antimicrobial and antitumoral activities. Nitric oxide is synthesized from L-arginine by nitric oxide synthases. Variations in this gene are associated with susceptibility to coronary spasm. Alternative splicing and the use of alternative promoters results in multiple transcript variants. [provided by RefSeq, Oct 2016]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO10217 | NOS3 Knockout cell line (HCT 116) | Human | NOS3 | 1:2~1:4 | Negative | Online Inquiry |
NOS3 Gene Knockout Cell Lines are specialized cellular models that have been genetically engineered to silence the endothelial nitric oxide synthase (NOS3) gene. This gene is crucial in the production of nitric oxide (NO), a signaling molecule involved in a multitude of physiological processes, including vasodilation, blood flow regulation, and neurotransmission. The precise mechanism of action of these knockout cell lines involves the elimination of the NOS3 gene, which subsequently leads to a significant decrease in NO production. This makes it an invaluable tool for researchers aiming to study the implications of impaired NO signaling in various pathological conditions such as cardiovascular diseases, neurodegenerative disorders, and metabolic syndromes.
From a scientific perspective, the NOS3 Gene Knockout Cell Lines serve as a model for elucidating the role of nitric oxide in cellular signaling pathways and disease mechanisms, facilitating advanced research in pharmacology and regenerative medicine. These cell lines can be employed in drug discovery processes, where the impact of therapeutic compounds on NOS3-deficient environments can unveil novel treatment strategies. In clinical settings, understanding the implications of NOS3 knockout may lead to breakthroughs in managing diseases characterized by endothelial dysfunction.
What sets our NOS3 Gene Knockout Cell Lines apart from alternatives is their high specificity, robust genetic modification process, and comprehensive validation to ensure consistent experimental results. Additionally, these cell lines are readily adaptable for high-throughput screening assays, making them accessible for a variety of research needs.
For researchers and clinicians, the value of the NOS3 Gene Knockout Cell Lines lies not only in their innovative approach to studying molecular mechanisms but also in their potential to contribute to the development of novel therapeutic interventions. The insights gained from using these models can lead to a deeper understanding of nitric oxide's role in human health and disease.
At our company, we pride ourselves on our expertise in providing high-quality biological products that empower advancements in scientific research and clinical applications. Our commitment to excellence ensures that our NOS3 Gene Knockout Cell Lines are a reliable choice for any laboratory aiming to push the boundaries of current biomedical research.
Please note that all services are for research use only. Not intended for any clinical use.
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