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NOS1AP Knockout Cell Lines

Gene: NOS1AP

Official Full Name: nitric oxide synthase 1 adaptor proteinprovided by HGNC

Gene Summary: This gene encodes a cytosolic protein that binds to the signaling molecule, neuronal nitric oxide synthase (nNOS). This protein has a C-terminal PDZ-binding domain that mediates interactions with nNOS and an N-terminal phosphotyrosine binding (PTB) domain that binds to the small monomeric G protein, Dexras1. Studies of the related mouse and rat proteins have shown that this protein functions as an adapter protein linking nNOS to specific targets, such as Dexras1 and the synapsins. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2009]

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Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO32854 NOS1AP Knockout cell line (HCT 116) Human NOS1AP 1:2~1:4 Negative Online Inquiry
KO32855 NOS1AP Knockout cell line (HEK293) Human NOS1AP 1:3~1:6 Negative Online Inquiry

Background

NOS1AP Gene Knockout Cell Lines are specialized biological models created through targeted genomic editing that enables researchers to investigate the functional implications of the nitric oxide synthase 1 adaptor protein (NOS1AP) in various cellular processes. By purposefully disrupting the NOS1AP gene, these cell lines facilitate studies into its role in neuronal signaling, cardiovascular function, and neurodegenerative diseases.

The primary function of these knockout cell lines lies in their ability to mimic the physiological conditions of NOS1AP deficiency, thus elucidating the downstream biological pathways influenced by this protein. Researchers can employ a variety of assays to assess changes in nitric oxide signaling, cellular proliferation, apoptosis, or synaptic transmission, providing insights into the mechanistic basis of diseases associated with NOS1AP dysfunction.

The scientific importance of NOS1AP Gene Knockout Cell Lines extends into both fundamental research and translational applications. In a research context, they serve as vital tools for investigating novel therapeutic targets for conditions like schizophrenia and Alzheimer's disease, where NOS1AP has been implicated. Clinically, understanding the role of NOS1AP can lead to advances in personalized medicine, where tailored treatments could be developed based on individual genetic profiles.

What sets these cell lines apart from other knockout models is their specificity and the comprehensive validation provided by our development process. Each cell line is meticulously characterized to ensure reproducibility and reliability, giving researchers confidence in the data they generate. Additionally, the flexibility for use in a range of in vitro assays allows for diverse experimental designs.

The value of NOS1AP Gene Knockout Cell Lines to researchers and clinicians lies in their capability to bridge the gap between bench research and clinical application, offering innovative solutions for understanding complex biological systems. Our company prides itself on its commitment to high-quality biological products and expertise in genomic technologies, ensuring that our clients can access cutting-edge tools for their research needs.

Please note that all services are for research use only. Not intended for any clinical use.

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