Gene: NOMO2
Official Full Name: NODAL modulator 2provided by HGNC
Gene Summary: This gene encodes a protein originally thought to be related to the collagenase gene family. This gene is one of three highly similar genes in a region of duplication located on the p arm of chromosome 16. These three genes encode closely related proteins that may have the same function. The protein encoded by one of these genes has been identified as part of a protein complex that participates in the Nodal signaling pathway during vertebrate development. Mutations in ABCC6, which is located nearby, rather than mutations in this gene are associated with pseudoxanthoma elasticum (PXE). Two transcripts encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO20936 | NOMO2 Knockout cell line (HeLa) | Human | NOMO2 | 1:3~1:6 | Negative | Online Inquiry |
KO20937 | NOMO2 Knockout cell line (HCT 116) | Human | NOMO2 | 1:2~1:4 | Negative | Online Inquiry |
KO20938 | NOMO2 Knockout cell line (HEK293) | Human | NOMO2 | 1:3~1:6 | Negative | Online Inquiry |
KO20939 | NOMO2 Knockout cell line (A549) | Human | NOMO2 | 1:3~1:4 | Negative | Online Inquiry |
NOMO2 Gene Knockout Cell Lines are precision-engineered cellular models that have been genetically modified to lack the expression of the NOMO2 gene, known to play a critical role in developmental processes, particularly in the signaling pathways regulating cell differentiation and tissue patterning. By ablating this gene, researchers gain insight into the molecular mechanisms underlying various biological phenomena, including embryonic development and disease pathogenesis.
The primary mechanism employed in generating NOMO2 knockout cell lines involves CRISPR/Cas9 gene-editing technology, which introduces targeted mutations in the NOMO2 gene locus. This process not only enables the creation of a heterogenous pool of cells but also allows for the validation of functional studies that elucidate the gene's role. When utilized as a research tool, these knockout cell lines facilitate the exploration of signaling pathways influenced by NOMO2, hence broadening our understanding of crucial developmental roles and potential implications in disorders such as congenital abnormalities.
In the context of scientific research and clinical applications, the NOMO2 Gene Knockout Cell Lines serve as invaluable resources. They can be employed for drug screening, functional genomics, and the study of gene interactions. Their ability to replicate conditions found in human development makes them particularly advantageous for developmental biology studies, regenerative medicine, and therapeutic interventions.
Compared to alternative cell lines that may retain NOMO2 expression, these knockout models provide a distinct advantage by allowing researchers to dissect NOMO2's contributions without interference from its normal function. This specificity not only enhances experimental clarity but also accelerates the discovery of innovative treatment strategies.
The value of the NOMO2 Gene Knockout Cell Lines to researchers and clinicians lies in their ability to unravel complex biological pathways and contribute to the development of targeted therapies. They represent a robust platform for investigating developmental cues and potential pathological mechanisms, thus empowering breakthroughs in both fundamental and applied biomedical sciences.
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