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NOCT Knockout Cell Lines

Gene: NOCT

Official Full Name: nocturninprovided by HGNC

Gene Summary: The protein encoded by this gene is highly similar to Nocturnin, a gene identified as a circadian clock regulated gene in Xenopus laevis. This protein and Nocturnin protein share similarity with the C-terminal domain of a yeast transcription factor, carbon catabolite repression 4 (CCR4). The mRNA abundance of a similar gene in mouse has been shown to exhibit circadian rhythmicity, which suggests a role for this protein in clock function or as a circadian clock effector. [provided by RefSeq, Jul 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO28770 NOCT Knockout cell line (HeLa) Human NOCT 1:3~1:6 Negative Online Inquiry
KO28771 NOCT Knockout cell line (HCT 116) Human NOCT 1:2~1:4 Negative Online Inquiry
KO28772 NOCT Knockout cell line (HEK293) Human NOCT 1:3~1:6 Negative Online Inquiry
KO28773 NOCT Knockout cell line (A549) Human NOCT 1:3~1:4 Negative Online Inquiry

Background

NOCT Gene Knockout Cell Lines are genetically engineered cell models designed to facilitate targeted gene disruption for functional studies. By utilizing advanced CRISPR-Cas9 technology, these knockout cell lines enable researchers to systematically deactivate specific genes of interest, allowing for the observation and analysis of phenotypic changes that arise from gene loss. The process involves the precise insertion of guide RNAs and Cas9 endonuclease, leading to double-strand breaks in the target DNA and subsequent non-homologous end joining (NHEJ), which disrupts gene function.

The key function of NOCT Gene Knockout Cell Lines is their ability to serve as versatile platforms for elucidating gene function, studying disease mechanisms, and assessing therapeutic targets. These models have profound implications in various fields including oncology, neurology, and developmental biology. Their use in clinical research as a means to better understand gene involvement in specific diseases has the potential to accelerate drug discovery and development processes.

One of the standout advantages of NOCT Gene Knockout Cell Lines is their specificity and reproducibility compared to traditional knockout strategies, such as those involving homologous recombination or RNA interference. This specificity results in minimal off-target effects, allowing for more reliable experimental outcomes. Additionally, these cell lines are readily available and can be easily adapted to various experimental conditions, making them an accessible choice for both academic and industrial laboratories.

For researchers and clinicians, the ability to create or utilize precise gene knockouts elevates the potential for impactful discoveries and innovations in personalized medicine. The comprehensive nature of these models not only enhances the understanding of gene function but also bridges the gap between basic research and clinical application.

Our company is committed to advancing the field of molecular biology by providing cutting-edge tools like the NOCT Gene Knockout Cell Lines, backed by years of expertise in genetic engineering and cellular biology. By choosing our products, researchers gain access to a wealth of knowledge and support, ensuring their studies are equipped for success.

Please note that all services are for research use only. Not intended for any clinical use.

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