Gene: NNMT
Official Full Name: nicotinamide N-methyltransferaseprovided by HGNC
Gene Summary: N-methylation is one method by which drug and other xenobiotic compounds are metabolized by the liver. This gene encodes the protein responsible for this enzymatic activity which uses S-adenosyl methionine as the methyl donor. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO05069 | NNMT Knockout cell line (HeLa) | Human | NNMT | 1:3~1:6 | Negative | Online Inquiry |
KO05070 | NNMT Knockout cell line (A549) | Human | NNMT | 1:3~1:4 | Negative | Online Inquiry |
NNMT Gene Knockout Cell Lines are engineered cellular models designed to specifically disrupt the expression of the NNMT (nicotinamide N-methyltransferase) gene. Utilizing CRISPR/Cas9 gene-editing technology, these cell lines enable precise modification of the genome, rendering the NNMT gene inactive. This knockout allows researchers to investigate the gene's biological roles, metabolic pathways, and its implications in various physiological and disease contexts.
The key function of the NNMT Gene Knockout Cell Lines lies in their ability to elucidate the effects of NNMT absence on cellular metabolism, namely its relationship to lipid metabolism and methylation processes. By providing a controlled environment where NNMT function can be selectively removed, researchers can study the downstream effects on cellular signaling, energy metabolism, and potential roles in metabolic disorders, including obesity and diabetes.
Scientifically, these cell lines hold great importance in both research and clinical settings. They can be employed in drug discovery processes to identify potential therapeutic targets associated with NNMT, enhancing our understanding of its role in pathologies like cancer and cardiovascular diseases. Utilizing these knockout lines accelerates research and provides a robust platform for testing hypotheses related to metabolic dysregulation.
What sets our NNMT Gene Knockout Cell Lines apart from alternatives is their high specificity and reliability, underpinned by our rigorous quality control protocols. Unlike traditional methods, which may yield off-target effects or incomplete knockouts, our carefully designed cell lines ensure precise gene deletion, thereby maximizing experimental accuracy and reproducibility.
For researchers, clinicians, and academic institutions, the NNMT Gene Knockout Cell Lines represent an invaluable tool that unlocks new avenues in metabolic research, ultimately advancing therapeutic strategies. Trust in our product offerings stems from our company's extensive expertise in synthetic biology and gene editing, assuring you of high-quality, cutting-edge biological tools that propel your research or clinical applications forward.
Please note that all services are for research use only. Not intended for any clinical use.
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