Gene: NME4
Official Full Name: NME/NM23 nucleoside diphosphate kinase 4provided by HGNC
Gene Summary: The nucleoside diphosphate (NDP) kinases (EC 2.7.4.6) are ubiquitous enzymes that catalyze transfer of gamma-phosphates, via a phosphohistidine intermediate, between nucleoside and dioxynucleoside tri- and diphosphates. The enzymes are products of the nm23 gene family, which includes NME4 (Milon et al., 1997 [PubMed 9099850]).[supplied by OMIM, May 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO04840 | NME4 Knockout cell line (HeLa) | Human | NME4 | 1:3~1:6 | Negative | Online Inquiry |
KO04841 | NME4 Knockout cell line (HCT 116) | Human | NME4 | 1:2~1:4 | Negative | Online Inquiry |
KO04842 | NME4 Knockout cell line (HEK293) | Human | NME4 | 1:3~1:6 | Negative | Online Inquiry |
KO04843 | NME4 Knockout cell line (A549) | Human | NME4 | 1:3~1:4 | Negative | Online Inquiry |
NME4 Gene Knockout Cell Lines are an advanced biological tool designed specifically for the study of the NME4 gene's functions in various cellular processes. These specialized cell lines have undergone targeted gene editing, resulting in the complete disruption of NME4 expression. By providing a clear model for researchers, these knockout cell lines enable precise investigation into the roles of NME4 in cell signaling, proliferation, and apoptosis, illuminating the gene's contribution to pathophysiological conditions, such as cancer and metabolic disorders.
The primary mechanism of action lies in CRISPR/Cas9 technology, which allows for the efficient creation of gene knockouts with minimal off-target effects. By utilizing these cutting-edge methods, the NME4 Gene Knockout Cell Lines facilitate a deeper understanding of molecular pathways and help to define the consequences of NME4 loss. This is critical for elucidating its potential as a therapeutic target or biomarker in clinical settings.
The scientific importance of these cell lines is profound; they offer researchers a consistent and reliable model for drug discovery, gene therapy research, and developmental biology studies. In clinical settings, identifying the functions of NME4 can significantly inform therapeutic strategies for diseases linked to its dysregulation.
What sets NME4 Gene Knockout Cell Lines apart from competing products is their rigorous validation and characterization, ensuring researchers can trust their findings. Additionally, with our dedicated support team, users can benefit from expert guidance on experimental design and troubleshooting, streamlining their research process.
For researchers and clinicians seeking to advance their work, these cell lines offer unparalleled insights into gene function and potential clinical applications. Our company prides itself on its expertise in molecular biology and genetic engineering, consistently delivering high-quality products that empower scientific breakthroughs and facilitate innovative research.
Please note that all services are for research use only. Not intended for any clinical use.
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