Gene: NLRP2
Official Full Name: NLR family pyrin domain containing 2provided by HGNC
Gene Summary: This gene is a member of the nucleotide-binding and leucine-rich repeat receptor (NLR) family, and is predicted to contain an N-terminal pyrin effector domain (PYD), a centrally-located nucleotide-binding and oligomerization domain (NACHT) and C-terminal leucine-rich repeats (LRR). Members of this gene family are thought to be important regulators of immune responses. This gene product interacts with components of the IkB kinase (IKK) complex, and can regulate both caspase-1 and NF-kB (nuclear factor kappa-light-chain-enhancer of activated B cells) activity. The pyrin domain is necessary and sufficient for suppression of NF-kB activity. An allelic variant (rs147585490) has been found that is incapable of blocking the transcriptional activity of NF-kB. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2016]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO15711 | NLRP2 Knockout cell line (HCT 116) | Human | NLRP2 | 1:2~1:4 | Negative | Online Inquiry |
KO15712 | NLRP2 Knockout cell line (A549) | Human | NLRP2 | 1:3~1:4 | Negative | Online Inquiry |
NLRP2 Gene Knockout Cell Lines are genetically engineered cellular models designed to facilitate the study of the NLRP2 (NOD-Like Receptor Pyroptosis Domain Containing 2) gene's function in immune responses and inflammatory processes. These cell lines have been meticulously created through cutting-edge CRISPR-Cas9 technology, effectively disabling the NLRP2 gene's functionality. This tool enables researchers to elucidate the precise role NLRP2 plays in pathways involved in innate immunity, apoptosis, and inflammation.
The key functions of these knockout cell lines allow for a rigorous examination of the biological mechanisms underlying NLRP2's involvement in cellular signaling pathways. By comparing the knockout lines to wild-type counterparts, scientists can identify alterations in cytokine release, apoptosis, and other physiological processes triggered by pathological conditions. Furthermore, these models provide invaluable insights into the gene's correlation with various diseases, including autoimmune disorders and certain cancers, by facilitating the study of gene-environment interactions in controlled settings.
From a scientific standpoint, NLRP2 knockout cell lines represent a significant advancement in the toolkit available for researchers investigating immune-related pathways. They hold immense potential for clinical applications, notably in drug discovery and therapeutic target validation, enhancing the translation of laboratory findings into treatment strategies for various diseases.
What sets these knockout cell lines apart from alternatives is their high fidelity and specificity, providing researchers with robust and reliable data that are crucial for drawing meaningful conclusions. The incorporation of the latest genome-editing technologies ensures that these models provide a level of precision and reproducibility that is often lacking in traditional approaches.
For researchers, clinicians, and pharmaceutical developers grappling with questions related to NLRP2, the availability of these knockout cell lines represents an invaluable resource that streamlines experimental workflows and delivers impactful insights. Our company, specializing in high-quality biological products, leverages its expertise in genetic engineering and cell biology to offer cutting-edge tools like the NLRP2 Gene Knockout Cell Lines, ensuring that researchers have access to the best resources for advancing their work and transforming scientific knowledge into clinical applications.
Please note that all services are for research use only. Not intended for any clinical use.
If your question is not addressed through these resources, you can fill out the online form below and we will answer your question as soon as possible.
There is no product in your cart. |
CD Biosynsis is a leading customer-focused biotechnology company dedicated to providing high-quality products, comprehensive service packages, and tailored solutions to support and facilitate the applications of synthetic biology in a wide range of areas.