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NIPA2 Knockout Cell Lines

Gene: NIPA2

Official Full Name: NIPA magnesium transporter 2provided by HGNC

Gene Summary: This gene encodes a possible magnesium transporter. This gene is located adjacent to the imprinted domain in the Prader-Willi syndrome deletion region of chromosome 15. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 3, 7 and 21.[provided by RefSeq, May 2010]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO25678 NIPA2 Knockout cell line (HeLa) Human NIPA2 1:3~1:6 Negative Online Inquiry
KO25679 NIPA2 Knockout cell line (HCT 116) Human NIPA2 1:2~1:4 Negative Online Inquiry
KO25680 NIPA2 Knockout cell line (HEK293) Human NIPA2 1:3~1:6 Negative Online Inquiry
KO25681 NIPA2 Knockout cell line (A549) Human NIPA2 1:3~1:4 Negative Online Inquiry

Background

NIPA2 Gene Knockout Cell Lines are genetically engineered cellular models that have had the NIPA2 gene specifically disrupted, allowing researchers to study the functional implications of this gene in various biological processes. NIPA2, or the Non-Imprinted in Prader-Willi/Angelman Syndrome 2 gene, is implicated in multiple physiological roles, including osmoregulation and cellular signaling pathways. By creating knockout models, scientists can observe changes in cellular behavior, metabolic pathways, and gene expression that are linked to the absence of NIPA2.

The key mechanism of our NIPA2 Gene Knockout Cell Lines lies in the use of CRISPR-Cas9 technology to achieve a precise and efficient mutational event at the NIPA2 locus. This approach facilitates not just the study of NIPA2’s function but also the phenotypic consequences resulting from its knockout, making it a valuable tool for elucidating the gene’s role in health and disease. These cell lines serve as crucial models for understanding genetic contributions to disorders like Prader-Willi syndrome and Angelman syndrome, thus bridging significant gaps in biomedical research.

In scientific and clinical settings, these knockout cell lines are instrumental for drug discovery, toxicity testing, and modeling genetic disorders. Their availability accelerates research efforts and provides a platform for therapeutic advancements aimed at restoring normal function in affected pathways. When compared to alternative models that may be less specific or lack precise gene editing, our NIPA2 Gene Knockout Cell Lines provide enhanced accuracy, reproducibility, and reliability in experimental applications.

Researchers and clinicians benefit significantly from using our product, as it not only advances their understanding of NIPA2’s biological role but also supports the development of innovative therapies targeting related conditions. With our commitment to quality and precision, our organization is dedicated to providing top-tier biological research tools, including these knockout cell lines, to empower scientists in their quest for discovery and clinical application.

Please note that all services are for research use only. Not intended for any clinical use.

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