Gene: NGEF
Official Full Name: neuronal guanine nucleotide exchange factorprovided by HGNC
Gene Summary: Enables guanyl-nucleotide exchange factor activity. Predicted to be involved in ephrin receptor signaling pathway; regulation of actin cytoskeleton organization; and regulation of synapse organization. Predicted to be located in cytosol. Predicted to be active in glutamatergic synapse and postsynapse. [provided by Alliance of Genome Resources, Apr 2025]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO28832 | NGEF Knockout cell line (HeLa) | Human | NGEF | 1:3~1:6 | Negative | Online Inquiry |
KO28833 | NGEF Knockout cell line (HCT 116) | Human | NGEF | 1:2~1:4 | Negative | Online Inquiry |
KO28834 | NGEF Knockout cell line (HEK293) | Human | NGEF | 1:3~1:6 | Negative | Online Inquiry |
KO28835 | NGEF Knockout cell line (A549) | Human | NGEF | 1:3~1:4 | Negative | Online Inquiry |
NGEF Gene Knockout Cell Lines are genetically engineered cell lines specifically designed to explore the functional implications of the NGEF gene in various biological contexts. Gene knockout techniques involve the targeted disruption of specific genes, allowing researchers to study the resulting phenotypic changes and understand the physiological roles of these genes. The NGEF gene, known for its involvement in neuronal signaling and cytoskeletal regulation, provides significant insights into cellular mechanisms and disease pathologies when ablated.
These cell lines exhibit a complete loss of NGEF expression, enabling a detailed analysis of its biological pathways and interactions. The mechanisms at play include altered cell signaling, modification of cellular morphology, and variations in cellular response to external stimuli. This targeted approach can elucidate the gene's role in neurodegenerative diseases, cancer progression, and developmental biology, positioning the NGEF knockout lines as invaluable tools in both basic and applied research.
In contrast to traditional research methods that rely on pharmacological inhibition or overexpression systems, the NGEF Gene Knockout Cell Lines offer a more precise means to dissect gene function. Researchers can utilize these lines to generate models that more accurately reflect genetic disruptions observed in pathophysiological conditions, making findings more relevant and translatable to clinical settings.
For researchers and clinicians aiming to gain insights into NGEF-related pathways, the NGEF Gene Knockout Cell Lines empower investigations with high specificity and reproducibility. Additionally, they are an essential asset for pharmaceutical companies seeking new avenues for therapeutic development based on genetic interventions.
With years of expertise in gene editing technologies and a commitment to advancing biological research, our company stands as a leader in providing high-quality genetic model systems, including the NGEF Gene Knockout Cell Lines. Our products are designed to meet the rigorous demands of modern science and foster innovation across diverse biological genres.
Please note that all services are for research use only. Not intended for any clinical use.
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