Home / NFYA Knockout Cell Lines

NFYA Knockout Cell Lines

Gene: NFYA

Official Full Name: nuclear transcription factor Y subunit alphaprovided by HGNC

Gene Summary: The protein encoded by this gene is one subunit of a trimeric complex, forming a highly conserved transcription factor that binds to CCAAT motifs in the promoter regions in a variety of genes. Subunit A associates with a tight dimer composed of the B and C subunits, resulting in a trimer that binds to DNA with high specificity and affinity. The sequence specific interactions of the complex are made by the A subunit, suggesting a role as the regulatory subunit. In addition, there is evidence of post-transcriptional regulation in this gene product, either by protein degradation or control of translation. Further regulation is represented by alternative splicing in the glutamine-rich activation domain, with clear tissue-specific preferences for the two isoforms. [provided by RefSeq, Jul 2008]

Get A Quote
Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO36350 NFYA Knockout cell line (HeLa) Human NFYA 1:3~1:6 Negative Online Inquiry
KO36351 NFYA Knockout cell line (HCT 116) Human NFYA 1:2~1:4 Negative Online Inquiry
KO36352 NFYA Knockout cell line (HEK293) Human NFYA 1:3~1:6 Negative Online Inquiry
KO36353 NFYA Knockout cell line (A549) Human NFYA 1:3~1:4 Negative Online Inquiry

Background

NFYA Gene Knockout Cell Lines are genetically engineered cellular models designed to investigate the functional roles of the NFYA gene, which encodes a member of the nuclear transcription factor Y complex involved in essential biological processes such as gene regulation, cell cycle control, and responses to stress. By utilizing CRISPR-Cas9 technology, these cell lines exhibit a targeted disruption of the NFYA gene, enabling researchers to examine the downstream effects of NFYA deficiency on cellular mechanisms.

The primary function of NFYA Gene Knockout Cell Lines is to provide a reliable platform for identifying the influence of the NFYA transcription factor in various physiological responses and disease states. Disruption of NFYA can lead to altered expression of genes involved in critical pathways, providing insights into cancer progression, cellular metabolism, and developmental biology. The knockout mechanism facilitates the assessment of specific phenotypic changes resulting from NFYA loss, which can help elucidate its roles in cellular homeostasis and pathological conditions.

Scientifically, these cell lines hold significant importance in both research and clinical applications. They can be utilized to explore gene therapy approaches, develop potential therapeutic interventions, and improve our understanding of gene function in human health and disease. With rising interest in personalized medicine, NFYA Gene Knockout Cell Lines offer valuable insights that could guide the development of targeted treatments and biomarkers.

Advantages of these cell lines over conventional models include high specificity in gene targeting, reduced off-target effects, and versatility in experimental applications. They maintain consistent growth patterns and phenotypic characteristics, thereby ensuring reliable and reproducible results, making them an essential tool for academic and pharmaceutical laboratories.

The value of NFYA Gene Knockout Cell Lines extends to researchers and clinicians aiming to unlock novel therapeutic avenues, as well as to those seeking to deepen their understanding of gene function and its implications in health and disease. Leveraging decades of expertise in genetic engineering and cell line development, our company delivers high-quality, validated products that empower the scientific community to make groundbreaking discoveries in molecular biology and translational research.

Please note that all services are for research use only. Not intended for any clinical use.

Get a free quote

If your question is not addressed through these resources, you can fill out the online form below and we will answer your question as soon as possible.

0

There is no product in your cart.