Gene: NFKBIZ
Official Full Name: NFKB inhibitor zetaprovided by HGNC
Gene Summary: This gene is a member of the ankyrin-repeat family and is induced by lipopolysaccharide (LPS). The C-terminal portion of the encoded product which contains the ankyrin repeats, shares high sequence similarity with the I kappa B family of proteins. The latter are known to play a role in inflammatory responses to LPS by their interaction with NF-B proteins through ankyrin-repeat domains. Studies in mouse indicate that this gene product is one of the nuclear I kappa B proteins and an activator of IL-6 production. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO15764 | NFKBIZ Knockout cell line (HeLa) | Human | NFKBIZ | 1:3~1:6 | Negative | Online Inquiry |
KO15765 | NFKBIZ Knockout cell line (HCT 116) | Human | NFKBIZ | 1:2~1:4 | Negative | Online Inquiry |
KO15766 | NFKBIZ Knockout cell line (HEK293) | Human | NFKBIZ | 1:3~1:6 | Negative | Online Inquiry |
KO15767 | NFKBIZ Knockout cell line (A549) | Human | NFKBIZ | 1:3~1:4 | Negative | Online Inquiry |
NFKBIZ Gene Knockout Cell Lines are genetically engineered cellular models that have been specifically developed to lack the NFKBIZ gene, which encodes a protein involved in the NF-kB signaling pathway, crucial for regulating immune response, inflammation, and cellular proliferation. By creating these knockout cell lines, researchers can investigate the specific roles of NFKBIZ in diverse biological processes and disease mechanisms.
These cell lines are instrumental in elucidating the functional dynamics of the NF-kB signaling pathway. Without the influence of NFKBIZ, researchers can better assess the ramifications on cellular responses to external stimuli such as cytokines or pathogen-associated molecular patterns. The knockout mechanism is achieved through advanced CRISPR/Cas9 technology, ensuring precise gene editing that allows for the elimination of NFKBIZ expression, providing a robust platform for functional studies.
The scientific importance of NFKBIZ Gene Knockout Cell Lines extends to their applications in research on inflammatory diseases, cancer biology, and immune system disorders. By delineating the contribution of NFKBIZ, these cell lines can facilitate the development of novel therapeutic strategies aimed at modulating immune responses and improving treatment outcomes.
One of the unique selling points of our NFKBIZ Gene Knockout Cell Lines is their unmatched reliability and consistency, attributes that are essential for replicable science. Unlike alternative models, which may exhibit variable expression levels of NFKBIZ or possess residual activity, these knockout lines provide a clean slate for researchers, ensuring confidence in their experimental outcomes. Additionally, our cell lines are optimized for ease of use and can be readily incorporated into any laboratory workflow.
With a commitment to innovation and scientific excellence, our company is dedicated to providing high-quality biological products that empower researchers and clinicians. Our expertise in genetic engineering and cellular biology ensures that we deliver cutting-edge solutions to meet the evolving demands of scientific exploration. Investing in NFKBIZ Gene Knockout Cell Lines enhances research capabilities and contributes to advancements in understanding complex biological systems.
Please note that all services are for research use only. Not intended for any clinical use.
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