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NFKBID Knockout Cell Lines

Gene: NFKBID

Official Full Name: NFKB inhibitor deltaprovided by HGNC

Gene Summary: Predicted to enable NF-kappaB binding activity. Predicted to be involved in T cell receptor signaling pathway; positive regulation of T-helper 17 cell differentiation; and regulation of gene expression. Predicted to act upstream of or within several processes, including negative regulation of T cell differentiation in thymus; negative regulation of canonical NF-kappaB signal transduction; and positive regulation of thymocyte apoptotic process. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2025]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO24622 NFKBID Knockout cell line (HeLa) Human NFKBID 1:3~1:6 Negative Online Inquiry
KO24623 NFKBID Knockout cell line (HCT 116) Human NFKBID 1:2~1:4 Negative Online Inquiry
KO24624 NFKBID Knockout cell line (A549) Human NFKBID 1:3~1:4 Negative Online Inquiry

Background

NFKBID Gene Knockout Cell Lines are genetically modified cellular models designed to study the functional implications of the NFKBID gene, which encodes the NF-kB inhibitor, a pivotal player in the regulation of immune responses and cellular inflammation. These cell lines have been meticulously engineered to create a targeted disruption of the NFKBID gene, enabling researchers to elucidate its role in various biological processes, particularly those associated with cancer, autoimmunity, and inflammatory diseases.

The key function of these knockout cell lines lies in their ability to provide insight into the NF-κB signaling pathway, a major regulator of gene expression in response to pro-inflammatory cytokines and stress. By knocking out the NFKBID gene, researchers can observe the resultant changes in NF-κB activity, signaling cascades, and cellular behaviors such as apoptosis, proliferation, and differentiation. The mechanisms involved showcase how the absence of NFKBID alters immune responses and influences tumorigenesis, thus facilitating a deeper understanding of pathological conditions and therapeutic targets.

From a scientific perspective, NFKBID Gene Knockout Cell Lines are invaluable in both research and clinical contexts. They serve as powerful tools for investigating molecular mechanisms underlying diseases and testing potential therapeutic compounds that modulate NF-κB signaling. With the rising interest in precision medicine, these cell lines can assist in developing personalized treatment strategies and evaluating drug efficacy in targeted populations.

Compared to alternatives such as transient knockdown approaches or wild-type cell line studies, our NFKBID Gene Knockout Cell Lines provide unparalleled stability and reproducibility, making them ideal for longitudinal studies. This genetic knockout design ensures a consistent and permanent alteration, allowing for clearer data interpretation and results that can be replicated across experiments.

For researchers and clinicians focused on understanding the intricacies of NF-κB signaling and its implications in various diseases, NFKBID Gene Knockout Cell Lines offer a reliable and effective resource. The profound insights gained from utilizing these models can lead to innovative treatments and impactful scientific discoveries.

Our company prides itself on delivering high-quality biological products supported by rigorous research and development. With expertise in genetic engineering and cell line production, we are committed to providing researchers with advanced tools that accelerate progress in the life sciences.

Please note that all services are for research use only. Not intended for any clinical use.

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