Gene: NFIL3
Official Full Name: nuclear factor, interleukin 3 regulatedprovided by HGNC
Gene Summary: The protein encoded by this gene is a transcriptional regulator that binds as a homodimer to activating transcription factor (ATF) sites in many cellular and viral promoters. The encoded protein represses PER1 and PER2 expression and therefore plays a role in the regulation of circadian rhythm. Three transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Feb 2014]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO05049 | NFIL3 Knockout cell line (HeLa) | Human | NFIL3 | 1:3~1:6 | Negative | Online Inquiry |
KO05050 | NFIL3 Knockout cell line (HCT 116) | Human | NFIL3 | 1:2~1:4 | Negative | Online Inquiry |
KO05051 | NFIL3 Knockout cell line (HEK293) | Human | NFIL3 | 1:3~1:6 | Negative | Online Inquiry |
KO05052 | NFIL3 Knockout cell line (A549) | Human | NFIL3 | 1:3~1:4 | Negative | Online Inquiry |
NFIL3 Gene Knockout Cell Lines are specifically engineered cellular models that have had the NFIL3 (Nuclear Factor Interleukin 3 Regulated) gene disrupted or knocked out. This product serves as a pivotal tool for researchers aiming to investigate the multifaceted roles of NFIL3 in immune response, hematopoiesis, and various metabolic processes. The knockout mechanism typically involves CRISPR-Cas9 technology or other genome editing techniques, which provide high specificity and efficiency in gene alteration.
These cell lines function by effectively eliminating the NFIL3 gene's expression, allowing for the study of loss-of-function effects on cellular behavior and pathway regulation. Researchers can utilize these models to unravel the gene's involvement in critical biological processes and disease mechanisms, particularly in oncology and autoimmune diseases. Given that NFIL3 plays a significant role in modulating the transcription of key cytokines and other genes involved in the immune response, the ability to study its knockout effects is invaluable for therapeutic target identification and validation.
The scientific importance of NFIL3 Gene Knockout Cell Lines extends to their applications in drug discovery and development, as they provide a platform for evaluating how potential therapeutic compounds influence NFIL3-related pathways. Compared to alternative models, such as wild-type cell lines or temporary knockdown systems, these knockout lines offer a stable and reproducible approach to studying long-term effects and cellular adaptations.
Researchers and clinicians can count on NFIL3 Gene Knockout Cell Lines to provide precise insights into NFIL3’s biological significance and potential therapeutic implications. The value of this product lies not only in its capacity for enabling groundbreaking research but also in its role as a reliable resource for developing innovative treatment strategies. With decades of experience in biological product development and a commitment to quality, our company ensures that each NFIL3 Gene Knockout Cell Line is crafted to meet the highest scientific standards, equipping researchers with the tools needed for success in their investigations.
Please note that all services are for research use only. Not intended for any clinical use.
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