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NFE2L3 Knockout Cell Lines

Gene: NFE2L3

Official Full Name: NFE2 like bZIP transcription factor 3provided by HGNC

Gene Summary: This gene encodes a member of the cap 'n' collar basic-region leucine zipper family of transcription factors. The encoded protein heterodimerizes with small musculoaponeurotic fibrosarcoma factors to bind antioxidant response elements in target genes. This protein is a membrane bound glycoprotein that is targeted to the endoplasmic reticulum and the nuclear envelope. Pseudogenes of this gene are found on chromosomes 16, 17, and 18. [provided by RefSeq, Mar 2009]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO33055 NFE2L3 Knockout cell line (HeLa) Human NFE2L3 1:3~1:6 Negative Online Inquiry
KO33056 NFE2L3 Knockout cell line (HCT 116) Human NFE2L3 1:2~1:4 Negative Online Inquiry
KO33057 NFE2L3 Knockout cell line (HEK293) Human NFE2L3 1:3~1:6 Negative Online Inquiry
KO33058 NFE2L3 Knockout cell line (A549) Human NFE2L3 1:3~1:4 Negative Online Inquiry

Background

NFE2L3 Gene Knockout Cell Lines are a specialized tool in molecular biology, developed to facilitate the study of the NFE2L3 gene, which encodes a key transcription factor involved in cellular responses to oxidative stress and inflammation. By employing CRISPR-Cas9 technology, these cell lines enable researchers to create specific disruptions in the NFE2L3 gene, thereby allowing for the examination of its role in various biological processes and disease states.

The primary function of the NFE2L3 Gene Knockout Cell Lines is to provide a controlled environment for studying the effects of the gene deletion on cellular pathways, particularly those involving antioxidant responses and cell survival mechanisms. By comparing these knockout lines to wild-type controls, scientists can elucidate the gene’s contribution to homeostasis, toxicity resistance, and tumorigenesis, leading to a deeper understanding of diseases such as cancer and neurodegenerative disorders.

Scientifically, NFE2L3 knockout models are invaluable in both research and clinical applications, as they aid in drug discovery and toxicity screening, essential for developing therapeutic strategies that target oxidative stress-related conditions. Their ability to mimic disease states in a controlled laboratory setting makes them an important asset for translational medicine.

Compared to alternative genetic manipulation tools, such as RNA interference or traditional gene knockout methods, NFE2L3 Gene Knockout Cell Lines offer precise gene editing with minimal off-target effects and higher efficiency. This precision enhances reproducibility in experiments and shortens the research timeline, making these cell lines a preferred choice for many laboratories.

For researchers and clinicians, the value of NFE2L3 Gene Knockout Cell Lines lies in their potential to advance knowledge in gene function and regulation while providing a robust platform for drug development and toxicological assessments.

Our company specializes in producing high-quality biological products and genetic materials, ensuring that our NFE2L3 Gene Knockout Cell Lines meet rigorous standards for reliability and efficacy in research applications. With a commitment to innovation and scientific excellence, we provide tools that empower scientific inquiry and advance healthcare solutions.

Please note that all services are for research use only. Not intended for any clinical use.

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