Gene: NEU3
Official Full Name: neuraminidase 3provided by HGNC
Gene Summary: This gene product belongs to a family of glycohydrolytic enzymes which remove sialic acid residues from glycoproteins and glycolipids. It is localized in the plasma membrane, and its activity is specific for gangliosides. It may play a role in modulating the ganglioside content of the lipid bilayer. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO31477 | NEU3 Knockout cell line (HeLa) | Human | NEU3 | 1:3~1:6 | Negative | Online Inquiry |
KO31478 | NEU3 Knockout cell line (HCT 116) | Human | NEU3 | 1:2~1:4 | Negative | Online Inquiry |
KO31479 | NEU3 Knockout cell line (HEK293) | Human | NEU3 | 1:3~1:6 | Negative | Online Inquiry |
KO31480 | NEU3 Knockout cell line (A549) | Human | NEU3 | 1:3~1:4 | Negative | Online Inquiry |
NEU3 Gene Knockout Cell Lines are engineered cellular models specifically designed to facilitate the study of the sialidase NEU3 gene and its associated biological functions. These cell lines have undergone precise gene editing technologies, such as CRISPR-Cas9, to effectively disable the NEU3 gene, allowing researchers to explore its role in cellular processes such as glycoprotein synthesis, cell signaling, and membrane dynamics. By creating a functional absence of NEU3, these cell lines serve as valuable tools in the elucidation of sialylation pathways and their implications in various disease states, including cancer, neurodegenerative disorders, and cardiovascular diseases.
The primary mechanism through which NEU3 influences cellular behavior is through the modulation of cell surface glycosylation patterns that affect interaction with extracellular matrices and signaling molecules. By utilizing NEU3 Gene Knockout Cell Lines, researchers can investigate the downstream effects of altered sialic acid profiles, offering insights into the mechanistic roles of NEU3 in both normal physiology and pathophysiology.
From a scientific standpoint, these knockout lines are pivotal in advancing understanding of complex biological phenomena and contributing to drug discovery and therapeutic development. By enabling the identification of novel therapeutic targets that arise from NEU3 signaling pathways, these models can accelerate innovation in clinical settings.
What sets the NEU3 Gene Knockout Cell Lines apart from other similar products is their high specificity and reproducibility. Coupled with extensive validation processes, these cell lines guarantee researchers reliable results that can be confidently translated into broader biological contexts. Additionally, they are compatible with a wide range of assays and experimental designs, making them an indispensable asset for both basic research and translational studies.
Investing in NEU3 Gene Knockout Cell Lines adds immense value for researchers and clinicians alike, enhancing their ability to investigate sialidase functions and develop novel strategies targeting related diseases. Our company is dedicated to providing high-quality, reliable biological products, backed by a commitment to scientific excellence and customer support, ensuring that our users have access to the most innovative tools in research.
Please note that all services are for research use only. Not intended for any clinical use.
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