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NEK10 Knockout Cell Lines

Gene: NEK10

Official Full Name: NIMA related kinase 10provided by HGNC

Gene Summary: Enables protein kinase activity. Involved in several processes, including mucociliary clearance; positive regulation of protein phosphorylation; and regulation of ERK1 and ERK2 cascade. Part of protein kinase complex. Implicated in primary ciliary dyskinesia 44. [provided by Alliance of Genome Resources, Apr 2025]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO21866 NEK10 Knockout cell line (HeLa) Human NEK10 1:3~1:6 Negative Online Inquiry
KO21867 NEK10 Knockout cell line (HCT 116) Human NEK10 1:2~1:4 Negative Online Inquiry
KO21868 NEK10 Knockout cell line (A549) Human NEK10 1:3~1:4 Negative Online Inquiry

Background

NEK10 Gene Knockout Cell Lines are specialized cellular systems where the NEK10 gene has been systematically inactivated, creating a powerful tool for researchers to explore the gene's functional roles. NEK10 (NIMA-related kinase 10) is implicated in cell cycle regulation and DNA repair processes. By utilizing these knockout cell lines, scientists can investigate the downstream effects of NEK10 loss, allowing for a deeper understanding of its contributions to cellular homeostasis, tumorigenesis, and other biological processes.

The mechanism of action for NEK10 knockout involves the complete abrogation of the NEK10 protein, resulting in a loss-of-function phenotype. This enables researchers to discern the gene's influence on various signaling pathways, cellular responses to stress, and interactions with other molecular components, particularly in the context of cancer biology. Additionally, NEK10 knockout cell lines serve as an ideal platform for drug screening and biomarker discovery, as they provide a clean genetic background to evaluate therapeutic interventions.

The scientific importance of NEK10 Gene Knockout Cell Lines extends to both basic research and applications within clinical settings, offering insights into cancer biology, regenerative medicine, and genetic disorders. Their application in functional genomics studies helps elucidate the role of NEK10 in disease mechanisms, paving the way for potential therapeutic strategies.

Compared to traditional cell lines, NEK10 knockout systems provide unique advantages by enabling specific gene investigations without the confounding effects of other genetic factors. These models exhibit reproducible performance and can facilitate high-throughput screening, thus enhancing the efficiency of research processes.

To researchers and clinicians, NEK10 Gene Knockout Cell Lines represent a valuable resource for dissecting the complexities of cell signaling and disease pathways. The precision of knockout technology combined with robust experimental characteristics enhances the ability to conduct impactful research.

At our company, we pride ourselves on a commitment to advancing scientific research through high-quality biological products. With a focus on the latest advancements in genetic engineering and cell line development, we empower scientists to make significant discoveries in their fields.

Please note that all services are for research use only. Not intended for any clinical use.

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