Gene: NEIL2
Official Full Name: nei like DNA glycosylase 2provided by HGNC
Gene Summary: This gene encodes a member of the Fpg/Nei family of DNA glycosylases. These glycosylases initiate the first step in base excision repair by cleaving oxidatively damaged bases and introducing a DNA strand break via their abasic site lyase activity. This enzyme is primarily associated with DNA repair during transcription and acts prefentially on cytosine-derived lesions, particularly 5-hydroxyuracil and 5-hydroxycytosine. It contains an N-terminal catalytic domain, a hinge region, and a C-terminal DNA-binding domain with helix-two-turn-helix and zinc finger motifs. This enzyme interacts with the X-ray cross complementing factor 1 scaffold protein as part of a multi-protein DNA repair complex. A pseudogene of this gene has been identified. [provided by RefSeq, Mar 2017]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO06716 | NEIL2 Knockout cell line (HeLa) | Human | NEIL2 | 1:3~1:6 | Negative | Online Inquiry |
KO06717 | NEIL2 Knockout cell line (HCT 116) | Human | NEIL2 | 1:2~1:4 | Negative | Online Inquiry |
KO06718 | NEIL2 Knockout cell line (HEK293) | Human | NEIL2 | 1:3~1:6 | Negative | Online Inquiry |
KO06719 | NEIL2 Knockout cell line (A549) | Human | NEIL2 | 1:3~1:4 | Negative | Online Inquiry |
NEIL2 Gene Knockout Cell Lines are specialized cellular models engineered to enable the systematic study of the NEIL2 gene, which encodes a key DNA glycosylase involved in the critical process of base excision repair. By knocking out the NEIL2 gene, these cell lines facilitate the exploration of the gene’s role in DNA repair mechanisms, cell cycle regulation, and responses to genotoxic stress, providing a compelling platform for researchers aiming to advance their understanding of genomic stability and cancer biology.
The functionality of NEIL2 Gene Knockout Cell Lines is rooted in their ability to mimic a specific genetic alteration. Utilizing CRISPR/Cas9 technology, this product offers a highly efficient method for generating stable cell lines devoid of the NEIL2 gene, ensuring that researchers can study the physiological and pathological consequences of its absence. These cell lines serve as valuable tools for elucidating the molecular pathways associated with DNA damage responses, cellular aging, and the induction of programmed cell death.
The scientific significance of NEIL2 Gene Knockout Cell Lines extends to both basic research and potential clinical applications. By investigating the consequences of NEIL2 depletion, researchers can uncover new insights into diseases associated with DNA repair deficiencies, including various cancers. Furthermore, the study of these cell lines may lead to novel therapeutic strategies that exploit vulnerabilities in DNA repair pathways.
What sets NEIL2 Gene Knockout Cell Lines apart from alternative models is their high specificity and reproducibility, as well as the streamlined process for generating and maintaining them. Unlike traditional knockout models, which may involve cumbersome techniques and prolonged timelines, our cell lines are ready to use immediately, allowing researchers to focus on their experiments without the added burden of generating a knockout model from scratch.
This product is invaluable to researchers and clinicians alike, offering a unique opportunity to dissect the role of NEIL2 in health and disease. By utilizing NEIL2 Gene Knockout Cell Lines, users can contribute to pioneering discoveries that will shape the future of therapeutic interventions targeted at DNA repair mechanisms.
Our company has a proven track record in providing high-quality biological products that meet rigorous scientific standards. With extensive expertise in cell line development and molecular biology, we are committed to supporting the research community with innovative solutions that propel scientific discovery.
Please note that all services are for research use only. Not intended for any clinical use.
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