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NECAP1 Knockout Cell Lines

Gene: NECAP1

Official Full Name: NECAP endocytosis associated 1provided by HGNC

Gene Summary: This gene encodes a protein containing two characteristic WXXF motifs. The encoded protein localizes to clathrin-coated vesicles, where it binds components of the adapter protein complexes and aids in endocytosis. Loss of function of this gene results in early infantile epileptic encephalopathy-21. There is a pseudogene for this gene on chromosome 7. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO28547 NECAP1 Knockout cell line (HeLa) Human NECAP1 1:3~1:6 Negative Online Inquiry
KO28548 NECAP1 Knockout cell line (HCT 116) Human NECAP1 1:2~1:4 Negative Online Inquiry
KO28549 NECAP1 Knockout cell line (HEK293) Human NECAP1 1:3~1:6 Negative Online Inquiry
KO28550 NECAP1 Knockout cell line (A549) Human NECAP1 1:3~1:4 Negative Online Inquiry

Background

NECAP1 Gene Knockout Cell Lines are genetically engineered cell models that have been specifically designed to lack the NECAP1 gene, which plays a key role in intracellular trafficking and cellular organization. These cell lines are crucial tools for studying the biochemistry of cellular processes and the pathophysiology of various diseases, as the deletion of the NECAP1 gene allows researchers to elucidate its functional relevance and potential contributions to disorders such as cancer or neurodegenerative diseases.

The NECAP1 gene encodes a protein involved in clathrin-mediated endocytosis, impacting the cellular uptake of various substances and influencing signaling pathways. By observing the behaviors of NECAP1 knockout cells, researchers can investigate the downstream effects of disrupted endocytic processes, gaining insight into how alterations in this mechanism contribute to disease progression. The ability to manipulate these cell lines further enables experiments such as drug screening, functional rescue assays, and pathway elucidation, aligning with contemporary needs in biomedical research and therapeutic development.

What sets NECAP1 Gene Knockout Cell Lines apart from alternative research tools is their specificity and the robustness of their genetic modification. Unlike temporary knockdown methods which may have transient effects, these stable knockout lines offer a consistent model for prolonged studies, eliminating variability in experimental replicates. This stability allows for the generation of high-quality data that can lead to more reliable conclusions in research.

The value of NECAP1 Gene Knockout Cell Lines is particularly pronounced for researchers and clinicians focused on elucidating disease mechanisms and exploring novel therapeutic options. Their precision and reliability enhance experimental design, ultimately facilitating advances in biological science and medicine.

Our company prides itself on producing high-quality, precisely engineered biological products that support cutting-edge research. Our extensive experience in gene modification techniques ensures that every product we offer meets stringent scientific standards, making NECAP1 Gene Knockout Cell Lines an indispensable resource for advancing your research objectives.

Please note that all services are for research use only. Not intended for any clinical use.

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