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NECAB3 Knockout Cell Lines

Gene: NECAB3

Official Full Name: N-terminal EF-hand calcium binding protein 3provided by HGNC

Gene Summary: The protein encoded by this gene interacts with the amino-terminal domain of the neuron-specific X11-like protein (X11L), inhibits the association of X11L with amyloid precursor protein through a non-competitive mechanism, and abolishes the suppression of beta-amyloid production by X11L. This protein, together with X11L, may play an important role in the regulatory system of amyloid precursor protein metabolism and beta-amyloid generation. The protein is phosphorylated by NIMA-related expressed kinase 2, and localizes to the Golgi apparatus. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO15784 NECAB3 Knockout cell line (HeLa) Human NECAB3 1:3~1:6 Negative Online Inquiry
KO15785 NECAB3 Knockout cell line (HCT 116) Human NECAB3 1:2~1:4 Negative Online Inquiry
KO15786 NECAB3 Knockout cell line (HEK293) Human NECAB3 1:3~1:6 Negative Online Inquiry
KO15787 NECAB3 Knockout cell line (A549) Human NECAB3 1:3~1:4 Negative Online Inquiry

Background

NECAB3 Gene Knockout Cell Lines are precisely engineered cellular models created to eliminate the expression of the NECAB3 gene, which is implicated in various cellular processes, including synaptic functionality and the regulation of calcium signaling. These knockout cell lines utilize advanced CRISPR-Cas9 technology for gene editing, enabling researchers to study the resulting phenotypic and molecular alterations in a controlled environment. By effectively silencing NECAB3, these models facilitate the investigation of its role in disease mechanisms, particularly neurological disorders where calcium dysregulation might play a crucial part.

The primary function of the NECAB3 Gene Knockout Cell Lines is to provide researchers with a robust tool for elucidating the biological pathways influenced by NECAB3 expression. This is achieved by analyzing changes in cellular morphology, signaling cascades, and transcriptional profiles post-knockout. As a result, these cell lines offer significant value in the realms of basic research as well as translational studies, where understanding the intricacies of gene function can contribute to the development of therapeutic strategies.

What sets NECAB3 Gene Knockout Cell Lines apart from alternative models is their high efficiency and precision, minimizing the off-target effects commonly observed in traditional gene editing methods. Furthermore, these cell lines are designed for easy propagation and maintenance, making them suitable for a range of experimental setups, from high-throughput screening to detailed mechanistic studies.

Researchers and clinicians alike will find exceptional value in the NECAB3 Gene Knockout Cell Lines, which not only advance our understanding of specific gene functions but also drive innovation in drug discovery and therapeutic interventions. The availability of this sophisticated model can accelerate research timelines and enhance reproducibility in scientific studies.

Our company is dedicated to providing high-quality biological products supported by rigorous scientific validation and expertise. With a strong foundation in cellular biology and gene editing technologies, we offer a comprehensive suite of products that empower an array of research applications, affirming our commitment to advancing science and fostering innovation.

Please note that all services are for research use only. Not intended for any clinical use.

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