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NDRG2 Knockout Cell Lines

Gene: NDRG2

Official Full Name: NDRG family member 2provided by HGNC

Gene Summary: This gene is a member of the N-myc downregulated gene family which belongs to the alpha/beta hydrolase superfamily. The protein encoded by this gene is a cytoplasmic protein that may play a role in neurite outgrowth. This gene may be involved in glioblastoma carcinogenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2017]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO15806 NDRG2 Knockout cell line (HeLa) Human NDRG2 1:3~1:6 Negative Online Inquiry
KO15807 NDRG2 Knockout cell line (HCT 116) Human NDRG2 1:2~1:4 Negative Online Inquiry
KO15808 NDRG2 Knockout cell line (HEK293) Human NDRG2 1:3~1:6 Negative Online Inquiry
KO15809 NDRG2 Knockout cell line (A549) Human NDRG2 1:3~1:4 Negative Online Inquiry

Background

NDRG2 Gene Knockout Cell Lines are specialized cellular models engineered to lack expression of the NDRG2 gene, which is known to play roles in various cellular processes, including cell growth, differentiation, and response to stress. By precisely eliminating NDRG2 function, these cell lines enable researchers to explore the gene’s contribution to pathological conditions such as cancer and neurodegenerative diseases.

The mechanism underlying the functionality of NDRG2 knockout cell lines involves the absence of the protein encoded by the NDRG2 gene, allowing scientists to elucidate the biological pathways influenced by NDRG2. This unique experimental tool facilitates the study of signaling cascades and gene regulatory networks altered in diseases, offering insights into therapeutic targets and disease mechanisms. Researchers can observe differences in cellular behaviors—such as proliferation, apoptosis, and migration—when compared to wild-type cell lines, enabling a clearer understanding of gene function.

From a scientific perspective, these cell lines are invaluable in both basic and applied research. They are particularly useful in drug discovery and development, as they allow scientists to identify potential drug candidates that can modify NDRG2-related pathways. In clinical settings, they may aid in understanding patient variability in disease susceptibility and treatment response, ultimately enhancing personalized medicine approaches.

Compared to alternative models, NDRG2 Gene Knockout Cell Lines offer precise knockout validation, allowing for reproducibility and authenticity in experimental results. They are often derived from commonly used cell types, making them compatible with existing research protocols and easier for labs to integrate into their studies.

By providing a robust platform for studying the NDRG2 gene’s functions, our product holds immense potential to contribute to groundbreaking discoveries in molecular biology and therapeutic development. Our company is committed to delivering high-quality biological products and supporting researchers with tools that accelerate scientific advancement and enhance experimental outcomes.

Please note that all services are for research use only. Not intended for any clinical use.

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