Gene: NDNF
Official Full Name: neuron derived neurotrophic factorprovided by HGNC
Gene Summary: Predicted to enable heparin binding activity. Involved in several processes, including cellular response to hypoxia; negative regulation of apoptotic process; and nitric oxide mediated signal transduction. Located in extracellular region. Is active in extracellular space. Implicated in hypogonadotropic hypogonadism. [provided by Alliance of Genome Resources, Apr 2025]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO15810 | NDNF Knockout cell line (HEK293) | Human | NDNF | 1:3~1:6 | Negative | Online Inquiry |
NDNF Gene Knockout Cell Lines are genetically engineered cell cultures that have undergone targeted gene disruption of the NDNF gene, which is implicated in various neurobiological processes. This advanced tool allows researchers to study the functional roles of NDNF in both normal physiological and pathological conditions, particularly within neurodegenerative disease models. The key mechanism behind these cell lines involves CRISPR-Cas9 technology, which facilitates precise deletions or modifications in the genomic DNA, permitting the exploration of gene function at a cellular level without off-target effects.
These knockout cell lines are of significant scientific importance, serving as invaluable resources for laboratories focused on the molecular underpinnings of neurological disorders. In the realm of research, they enable the investigation of synaptic transmission, neuronal plasticity, and the cellular responses to stressors that are crucial in understanding diseases such as Alzheimer's and Parkinson's. Clinically, findings derived from using NDNF knockout models can inform therapeutic strategies and potential drug targets aimed at modulating NDNF-related pathways.
Compared to other genetic knockouts, our NDNF Gene Knockout Cell Lines stand out due to their high specificity and robust performance in various assay applications, including gene expression studies, compound screening, and cellular phenotyping. The reliability of these cell lines fosters reproducibility, a cornerstone in biological research.
The value of NDNF Gene Knockout Cell Lines to researchers and clinicians lies in their ability to provide insights that drive innovation in treatment approaches and disease understanding. With our commitment to advancing scientific knowledge and our expertise in genetic engineering, our company brings unparalleled quality and support to ensure that your research achieves its fullest potential.
Please note that all services are for research use only. Not intended for any clinical use.
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