Gene: NCR3LG1
Official Full Name: natural killer cell cytotoxicity receptor 3 ligand 1provided by HGNC
Gene Summary: B7H6 belongs to the B7 family (see MIM 605402) and is selectively expressed on tumor cells. Interaction of B7H6 with NKp30 (NCR3; MIM 611550) results in natural killer (NK) cell activation and cytotoxicity (Brandt et al., 2009 [PubMed 19528259]).[supplied by OMIM, Jan 2011]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO15818 | NCR3LG1 Knockout cell line (HeLa) | Human | NCR3LG1 | 1:3~1:6 | Negative | Online Inquiry |
KO15819 | NCR3LG1 Knockout cell line (HCT 116) | Human | NCR3LG1 | 1:2~1:4 | Negative | Online Inquiry |
KO15820 | NCR3LG1 Knockout cell line (HEK293) | Human | NCR3LG1 | 1:3~1:6 | Negative | Online Inquiry |
KO15821 | NCR3LG1 Knockout cell line (A549) | Human | NCR3LG1 | 1:3~1:4 | Negative | Online Inquiry |
NCR3LG1 Gene Knockout Cell Lines are genetically modified cellular models designed to facilitate the study of immune regulation and signal transduction pathways associated with the NCR3LG1 gene. This gene encodes a protein that is involved in the interaction between natural killer (NK) cells and their target cells, playing a crucial role in modulating immune responses. By creating knockout models, researchers can dissect the functional consequences of the absence of NCR3LG1, providing insights into its role in immune evasion and tumor progression.
The primary mechanism underlying these cell lines is gene editing, achieved through techniques such as CRISPR/Cas9, which disrupts the NCR3LG1 gene specifically. This allows for the analysis of cellular behaviors, including proliferation, apoptosis, and cytokine secretion in the absence of this critical gene. Consequently, researchers can elucidate the role of NCR3LG1 in immune checkpoint pathways and therapeutic resistance, offering potential biomarkers for immunotherapy responses.
The scientific importance of NCR3LG1 Gene Knockout Cell Lines is manifested in their applications across various contexts, including cancer research, immunology, and drug development. They serve as invaluable tools in investigating NK cell functionality, enhancing our understanding of immune system dynamics, and developing targeted treatments for malignancies or autoimmune disorders.
What sets our NCR3LG1 knockout cell lines apart from alternatives is their rigorous validation for genetic integrity and functionality, ensuring researchers can rely on consistent and reproducible results. Additionally, they come with thorough documentation and user support, enabling seamless integration into existing research workflows.
For researchers and clinicians, the value of these cell lines lies in their capacity to unlock new avenues for therapeutic strategies and advancement in personalized medicine. By leveraging these advanced models, users can pave the way for breakthroughs in immune-based therapies.
Our company is dedicated to delivering high-quality biological products backed by extensive expertise and a commitment to advancing scientific discovery. With a focus on precision and reliability, we provide an array of models that empower the research community to push the boundaries of what is possible in bioscience.
Please note that all services are for research use only. Not intended for any clinical use.
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