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NCOA2 Knockout Cell Lines

Gene: NCOA2

Official Full Name: nuclear receptor coactivator 2provided by HGNC

Gene Summary: The protein encoded by this gene functions as a transcriptional coactivator for nuclear hormone receptors, including steroid, thyroid, retinoid, and vitamin D receptors. The encoded protein acts as an intermediary factor for the ligand-dependent activity of these nuclear receptors, which regulate their target genes upon binding of cognate response elements. This gene has been found to be involved in translocations that result in fusions with other genes in various cancers, including the lysine acetyltransferase 6A (KAT6A) gene in acute myeloid leukemia, the ETS variant 6 (ETV6) gene in acute lymphoblastic leukemia, and the hes related family bHLH transcription factor with YRPW motif 1 (HEY1) gene in mesenchymal chondrosarcoma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO05141 NCOA2 Knockout cell line (HeLa) Human NCOA2 1:3~1:6 Negative Online Inquiry
KO05142 NCOA2 Knockout cell line (HCT 116) Human NCOA2 1:2~1:4 Negative Online Inquiry
KO05143 NCOA2 Knockout cell line (HEK293) Human NCOA2 1:3~1:6 Negative Online Inquiry
KO05144 NCOA2 Knockout cell line (A549) Human NCOA2 1:3~1:4 Negative Online Inquiry

Background

NCOA2 Gene Knockout Cell Lines are specifically engineered cell lines that facilitate the study of the nuclear receptor coactivator 2 (NCOA2) by disabling the gene responsible for its production. NCOA2 is a crucial player in transcriptional regulation and has implications in various biological processes, including cellular growth and metabolism. By utilizing these knockout cell lines, researchers can investigate the functional roles of NCOA2 without the confounding effects of its expression, thereby providing a clearer understanding of its contributions to cellular physiology and potential disease states.

The key function of NCOA2 Gene Knockout Cell Lines is their ability to serve as a model for dissecting the signaling pathways involved in NCOA2-mediated processes. By analyzing cellular responses, gene expression profiles, and metabolic functions in the absence of NCOA2, researchers can identify underlying mechanisms of action and potential therapeutic targets. These cell lines can also be used in drug discovery processes to evaluate how NCOA2 knockout influences the efficacy of various compounds, making them indispensable tools in pharmacological research.

The scientific importance of these cell lines extends to their applications in oncology and metabolic disease research. Understanding the role of NCOA2 in different contexts can lead to the identification of biomarkers for cancer prognosis or potential metabolic disorders. Furthermore, their use in clinical settings can aid in the development of targeted therapies, improving patient outcomes.

Compared to alternative models such as transient knockdown systems or wild-type cells, NCOA2 Gene Knockout Cell Lines provide a stable and reliable system for long-term experiments. This genetic knockout approach ensures consistent results, reducing variability that is commonly associated with transient methods. Additionally, these cell lines can be readily adapted for high-throughput screening applications, which are vital for accelerating research timelines.

For researchers and clinicians looking to explore the intricacies of gene function, NCOA2 Gene Knockout Cell Lines represent a transformative resource. Their specific targeting of NCOA2 allows for a focused exploration of its downstream effects, leading to novel insights and advancements in biological research.

At [Your Company Name], we pride ourselves on our commitment to producing high-quality biological products that empower researchers and advance scientific discovery. Our expertise in genetic engineering and cellular biology ensures that our NCOA2 Gene Knockout Cell Lines meet rigorous standards of reliability and efficacy.

Please note that all services are for research use only. Not intended for any clinical use.

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