Gene: NCK1
Official Full Name: NCK adaptor protein 1provided by HGNC
Gene Summary: The protein encoded by this gene is one of the signaling and transforming proteins containing Src homology 2 and 3 (SH2 and SH3) domains. It is located in the cytoplasm and is an adaptor protein involved in transducing signals from receptor tyrosine kinases to downstream signal recipients such as RAS. Alternatively spliced transcript variants encoding different isoforms have been found. [provided by RefSeq, Jun 2010]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO03518 | NCK1 Knockout cell line (HeLa) | Human | NCK1 | 1:3~1:6 | Negative | Online Inquiry |
KO03519 | NCK1 Knockout cell line (HCT 116) | Human | NCK1 | 1:2~1:4 | Negative | Online Inquiry |
KO03520 | NCK1 Knockout cell line (HEK293) | Human | NCK1 | 1:3~1:6 | Negative | Online Inquiry |
KO03521 | NCK1 Knockout cell line (A549) | Human | NCK1 | 1:3~1:4 | Negative | Online Inquiry |
NCK1 Gene Knockout Cell Lines are genetically engineered cell lines in which the NCK1 gene has been systematically disrupted, resulting in the elimination of its expression. NCK1 (NCK adaptor protein 1) is a key player in signal transduction, particularly in processes related to cytoskeletal dynamics, cell migration, and the modulation of various signaling pathways, including those activated by receptor tyrosine kinases. The disruption of NCK1 allows researchers to examine the gene's specific functions, assess the consequences of its absence on cellular behavior, and elucidate its role in health and disease.
These knockout cell lines operate by employing CRISPR/Cas9 technology, ensuring precise and efficient gene editing that results in reliable and reproducible phenotypic alterations. By studying these cell lines, scientists can gain valuable insights into cellular processes such as differentiation, proliferation, and response to growth factors, thereby establishing a direct link to the implications of NCK1 in oncogenesis and other pathological conditions.
The scientific importance of NCK1 Gene Knockout Cell Lines lies in their broad applications in both research and clinical settings. They are instrumental in cancer research, where understanding the mechanisms underlying tumor progression and metastasis is crucial. Furthermore, these cell lines serve as powerful tools for drug discovery, particularly in screening for therapeutic compounds targeting signaling pathways linked to NCK1.
What sets our NCK1 Gene Knockout Cell Lines apart from alternatives is the robust validation process they undergo, ensuring their fidelity and performance. Our product offers a unique combination of specificity and reliability, providing researchers with consistent data that can be reproduced across multiple experiments. Enhanced functionalities, such as minimal off-target effects and high efficiency in gene disruption, make these cell lines an invaluable resource for advancing molecular biology studies.
The value of our NCK1 Gene Knockout Cell Lines extends beyond their scientific utility. Researchers and clinicians benefit from our commitment to quality and support, backed by years of expertise in genetic engineering and cell line development. Our mission is to empower scientific discovery and innovation, providing high-quality tools that pave the way for transformative research outcomes.
Please note that all services are for research use only. Not intended for any clinical use.
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