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NCEH1 Knockout Cell Lines

Gene: NCEH1

Official Full Name: neutral cholesterol ester hydrolase 1provided by HGNC

Gene Summary: Predicted to enable serine hydrolase activity. Predicted to be involved in ether lipid metabolic process. Predicted to act upstream of or within protein dephosphorylation and xenobiotic metabolic process. Located in membrane. [provided by Alliance of Genome Resources, Apr 2025]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO15836 NCEH1 Knockout cell line (HeLa) Human NCEH1 1:3~1:6 Negative Online Inquiry
KO15837 NCEH1 Knockout cell line (HCT 116) Human NCEH1 1:2~1:4 Negative Online Inquiry
KO15838 NCEH1 Knockout cell line (HEK293) Human NCEH1 1:3~1:6 Negative Online Inquiry
KO15839 NCEH1 Knockout cell line (A549) Human NCEH1 1:3~1:4 Negative Online Inquiry

Background

NCEH1 Gene Knockout Cell Lines are genetically modified cellular models designed to eliminate the expression of the NCEH1 gene, which plays a critical role in various biological pathways, including lipid metabolism and inflammatory responses. By utilizing CRISPR-Cas9 technology, these cell lines are engineered to provide a powerful tool for researchers aiming to elucidate the physiological and pathological functions of NCEH1, enabling in-depth study of its involvement in diseases such as obesity, diabetes, and neurodegeneration.

The primary function of NCEH1 involves the hydrolysis of neurotoxic lipid derivatives, which helps maintain cellular homeostasis. By providing a knockout model, researchers can dissect the consequences of NCEH1 deficiency and its effects on cellular signaling, metabolic processes, and potential biomarker discovery. Understanding how the loss of NCEH1 alters cellular behavior can significantly further drug development efforts targeting metabolic and neurodegenerative conditions.

Scientifically, the applications of NCEH1 knockouts extend beyond basic research; they serve as invaluable platforms for preclinical evaluations of therapeutic compounds, thus bridging the gap between experimental research and clinical applications. These cell lines provide a reliable and consistent system for screening potential drug candidates and understanding their efficacy in restoring normal cellular function.

What sets our NCEH1 Gene Knockout Cell Lines apart from alternatives is our rigorous validation process and the assurance of reproducibility. Each cell line is stringently tested for genetic modifications, functional viability, and consistency across multiple passages, ensuring researchers experience minimal variability in their experiments. These characteristics streamline experimental procedures, saving both time and resources.

Investing in our NCEH1 Gene Knockout Cell Lines enriches research capabilities by providing a specialized tool that can enhance understanding and innovation within the biopharmaceutical industry. Our commitment to excellence in biotechnology, combined with extensive expertise in genetic engineering, empowers researchers and clinicians alike with high-quality products that drive the future of scientific inquiry.

Please note that all services are for research use only. Not intended for any clinical use.

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