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NCALD Knockout Cell Lines

Gene: NCALD

Official Full Name: neurocalcin deltaprovided by HGNC

Gene Summary: This gene encodes a member of the neuronal calcium sensor (NCS) family of calcium-binding proteins. The protein contains an N-terminal myristoylation signal and four EF-hand calcium binding loops. The protein is cytosolic at resting calcium levels; however, elevated intracellular calcium levels induce a conformational change that exposes the myristoyl group, resulting in protein association with membranes and partial co-localization with the perinuclear trans-golgi network. The protein is thought to be a regulator of G protein-coupled receptor signal transduction. Several alternatively spliced variants of this gene have been determined, all of which encode the same protein; additional variants may exist but their biological validity has not been determined. [provided by RefSeq, Jul 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO25271 NCALD Knockout cell line (HEK293) Human NCALD 1:3~1:6 Negative Online Inquiry
KO25272 NCALD Knockout cell line (A549) Human NCALD 1:3~1:4 Negative Online Inquiry

Background

NCALD Gene Knockout Cell Lines are specifically engineered cellular models designed to lack the expression of the neurocalcin delta (NCALD) gene. These cell lines utilize CRISPR-Cas9 technology, a revolutionary tool in genetic editing, to effectively disrupt NCALD gene sequences, thereby enabling researchers to investigate the gene's role in physiological and pathological processes. Neurocalcin delta, a calcium-binding protein, is implicated in various cellular signaling pathways, particularly those associated with synaptic function and neurodevelopment.

The primary function of NCALD gene knockout cell lines is to facilitate the study of NCALD's involvement in conditions such as neurodegenerative diseases, synaptic dysfunction, and cancer. By removing the NCALD gene, scientists can elucidate the biological pathways influenced by this protein, assess compensatory mechanisms in signaling, and understand its contribution to cellular homeostasis. These models are crucial for examining how dysregulation of NCALD expression may lead to disease states, making them invaluable for preclinical drug development and therapeutic research.

One of the standout advantages of our NCALD gene knockout cell lines is their high specificity and efficiency in gene editing compared to traditional knockdown methods. While RNA interference approaches might lead to partial gene silencing, our cell lines provide complete loss of function, allowing for a more accurate dissection of the gene's role. Additionally, these cell lines are characterized by their stability and reproducibility across experiments, ensuring consistent results that are essential for scientific rigor.

Researchers and clinicians will find significant value in utilizing NCALD gene knockout cell lines, as they enhance understanding of critical biological processes and pave the way for the development of targeted therapies. Our product is tailored for laboratories engaged in cutting-edge research, facilitating new insights into various diseases.

With a commitment to advancing scientific understanding, our company brings years of expertise in genetic engineering and cell line development to offer high-quality, innovative biological products that meet the diverse needs of the research community.

Please note that all services are for research use only. Not intended for any clinical use.

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