Gene: NBPF3
Official Full Name: NBPF member 3provided by HGNC
Gene Summary: This gene is a member of the neuroblastoma breakpoint family (NBPF) which consists of dozens of recently duplicated genes primarily located in segmental duplications on human chromosome 1. This gene family has experienced its greatest expansion within the human lineage and has expanded, to a lesser extent, among primates in general. Members of this gene family are characterized by tandemly repeated copies of DUF1220 protein domains. DUF1220 copy number variations in human chromosomal region 1q21.1, where most DUF1220 domains are located, have been implicated in a number of developmental and neurogenetic diseases such as microcephaly, macrocephaly, autism, schizophrenia, cognitive disability, congenital heart disease, neuroblastoma, and congenital kidney and urinary tract anomalies. Altered expression of some gene family members is associated with several types of cancer. This gene family contains numerous pseudogenes. [provided by RefSeq, Feb 2013]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO25087 | NBPF3 Knockout cell line (HeLa) | Human | NBPF3 | 1:3~1:6 | Negative | Online Inquiry |
KO25088 | NBPF3 Knockout cell line (HCT 116) | Human | NBPF3 | 1:2~1:4 | Negative | Online Inquiry |
KO25089 | NBPF3 Knockout cell line (HEK293) | Human | NBPF3 | 1:3~1:6 | Negative | Online Inquiry |
KO25090 | NBPF3 Knockout cell line (A549) | Human | NBPF3 | 1:3~1:4 | Negative | Online Inquiry |
NBPF3 Gene Knockout Cell Lines are specialized cellular models that have undergone targeted genetic modification, specifically the knockout of the NBPF3 gene. This comprehensive genetic alteration facilitates the systematic study of the NBPF3 gene's role in biological processes, disease mechanisms, and cellular functions. By eliminating the expression of this gene, researchers can elucidate its contribution to disease phenotypes, including its involvement in neurodevelopmental disorders and certain cancers.
The key function of NBPF3 knockout cell lines lies in their ability to provide a controlled environment to investigate the downstream effects of NBPF3 gene loss. These cell lines utilize CRISPR-Cas9 technology, a revolutionary genome editing tool that allows precise deletions or modifications of specific gene sequences. As a result, researchers can observe alterations in gene expression, cellular signaling pathways, and phenotype changes, offering vital insights into the gene's physiological and pathological roles.
The scientific importance of these knockout cell lines extends into various research domains, particularly in functional genomics and pharmacogenomics. They serve as essential tools for drug discovery, aiding in the identification of novel therapeutic targets and in understanding the cellular mechanisms underpinning diseases associated with NBPF3 dysregulation. In clinical settings, the knowledge gained from these models can lead to improved diagnostic markers and more tailored treatment approaches.
What sets NBPF3 Gene Knockout Cell Lines apart from alternative models is their specificity and the reliability of data obtained from utilizing these well-characterized lines. Unlike general genetic models, NBPF3 knockout lines offer precision and reproducibility, which are crucial for studies requiring high fidelity. Furthermore, these models are optimized for high-throughput screening, making them ideal for large-scale studies.
Clinicians and researchers seeking to deepen their understanding of the NBPF3 gene's functions should consider the advantages of utilizing these knockout cell lines. The insights derived from their use can ultimately facilitate advancements in both basic research and therapeutic development.
Our company brings decades of expertise in genetic engineering and synthetic biology, ensuring that NBPF3 Gene Knockout Cell Lines meet the highest standards of quality and scientific integrity. With a commitment to supporting innovative research, we offer not just products, but essential tools in advancing biological discovery.
Please note that all services are for research use only. Not intended for any clinical use.
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