Gene: NBPF10
Official Full Name: NBPF member 10provided by HGNC
Gene Summary: This gene is a member of the neuroblastoma breakpoint family (NBPF) which consists of dozens of recently duplicated genes primarily located in segmental duplications on human chromosome 1. This gene family has experienced its greatest expansion within the human lineage and has expanded, to a lesser extent, among primates in general. Members of this gene family are characterized by tandemly repeated copies of DUF1220 protein domains. Gene copy number variations in the human chromosomal region 1q21.1, where most DUF1220 domains are located, have been implicated in a number of developmental and neurogenetic diseases such as microcephaly, macrocephaly, autism, schizophrenia, cognitive disability, congenital heart disease, neuroblastoma, and congenital kidney and urinary tract anomalies. Altered expression of some gene family members is associated with several types of cancer. This gene family contains numerous pseudogenes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO15844 | NBPF10 Knockout cell line (HeLa) | Human | NBPF10 | 1:3~1:6 | Negative | Online Inquiry |
KO15845 | NBPF10 Knockout cell line (HCT 116) | Human | NBPF10 | 1:2~1:4 | Negative | Online Inquiry |
KO15846 | NBPF10 Knockout cell line (HEK293) | Human | NBPF10 | 1:3~1:6 | Negative | Online Inquiry |
NBPF10 Gene Knockout Cell Lines are specialized cellular models generated through targeted gene editing to disrupt the expression of the NBPF10 gene, which is implicated in various cellular processes and disease mechanisms. These cell lines serve as a critical tool for researchers studying the functional roles of NBPF10 in development, neurobiology, and pathology. By creating a complete knockout of this gene, scientists can examine changes in cellular behavior, signaling pathways, and gene expression profiles, thereby advancing our understanding of its biological significance.
The key mechanism of action for these cell lines is the use of CRISPR-Cas9 technology to precisely edit the genome. This method allows for efficient and accurate gene disruption, enabling researchers to generate a stable line of cells with reduced or absent NBPF10 protein. Comprehensive phenotypic analysis can be conducted on these knockout cell lines, providing insights into cellular functions such as proliferation, differentiation, and response to stimuli, contributing valuable data that may inform therapeutic approaches.
In a clinical or research context, the ability to manipulate specific genes like NBPF10 represents a powerful strategy for elucidating their roles in disease states, such as cancer or neurological disorders. The implications are significant, potentially informing drug development and personalized medicine strategies that target these mechanisms.
What sets NBPF10 Gene Knockout Cell Lines apart from other genetic tools is their tailored specificity and reliability. Unlike general knockout models that could introduce off-target effects, these lines are precisely engineered to provide high fidelity in research experiments, ensuring reproducibility and accuracy.
For researchers and clinicians, utilizing NBPF10 Gene Knockout Cell Lines unlocks the potential to explore the nuanced roles of specific genes in disease pathology. This product is invaluable for obtaining definitive insights that can pave the way for innovative therapies and better diagnostic tools.
At our company, we pride ourselves on our expertise in developing advanced biological products that support cutting-edge research. Our commitment to quality and innovation ensures that our cell lines meet the rigorous standards required for impactful scientific discovery.
Please note that all services are for research use only. Not intended for any clinical use.
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