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NBEA Knockout Cell Lines

Gene: NBEA

Official Full Name: neurobeachinprovided by HGNC

Gene Summary: This gene encodes a member of a large, diverse group of A-kinase anchor proteins that target the activity of protein kinase A to specific subcellular sites by binding to its type II regulatory subunits. Brain-specific expression and coat protein-like membrane recruitment of a highly similar protein in mouse suggest an involvement in neuronal post-Golgi membrane traffic. Mutations in this gene may be associated with a form of autism. This gene and its expression are frequently disrupted in patients with multiple myeloma. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants may exist, but their full-length nature has not been determined.[provided by RefSeq, Feb 2011]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO27949 NBEA Knockout cell line (HeLa) Human NBEA 1:3~1:6 Negative Online Inquiry
KO27950 NBEA Knockout cell line (HCT 116) Human NBEA 1:2~1:4 Negative Online Inquiry
KO27951 NBEA Knockout cell line (HEK293) Human NBEA 1:3~1:6 Negative Online Inquiry
KO27952 NBEA Knockout cell line (A549) Human NBEA 1:3~1:4 Negative Online Inquiry

Background

NBEA Gene Knockout Cell Lines are expertly engineered cellular models designed to facilitate in-depth studies of gene function and associated biological pathways. Each cell line is specifically modified to support the complete knockout of the NBEA gene, allowing researchers to explore the implications of NBEA loss on cellular physiology and biochemistry. The precise mechanism of action involves the use of CRISPR-Cas9 gene-editing technology, which is utilized to generate targeted deletions within the NBEA gene, rendering these cells invaluable for both basic and applied research.

The scientific importance of NBEA Gene Knockout Cell Lines lies in their ability to contribute to our understanding of various disease mechanisms, particularly in neurodevelopmental disorders where NBEA is implicated. Their application spans both research laboratories and clinical settings, enabling investigators to study gene expression patterns, protein interactions, and metabolic changes that arise from the absence of NBEA. Furthermore, these knockout lines serve as critical tools for the development of novel therapeutic strategies, offering insights into potential avenues for gene therapy or small molecule interventions.

What sets NBEA Gene Knockout Cell Lines apart from alternative models is their user-friendly design and high reliability. Unlike traditional models that may involve lengthy and complex gene editing procedures, these pre-made knockout lines reduce the time and resources needed for researchers to obtain results. Additionally, they ensure consistent performance across experiments, markedly enhancing reproducibility and data integrity.

For researchers and clinicians seeking to elucidate genetic contributions to disease, NBEA Gene Knockout Cell Lines provide an exceptional resource that bridges the gap between basic research and translational applications. Our commitment to quality and precision in biological product development underlines our expertise in the field, ensuring that our offerings meet the highest scientific standards and empower advancements in research.

Please note that all services are for research use only. Not intended for any clinical use.

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