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NAP1L4 Knockout Cell Lines

Gene: NAP1L4

Official Full Name: nucleosome assembly protein 1 like 4provided by HGNC

Gene Summary: This gene encodes a member of the nucleosome assembly protein (NAP) family which can interact with both core and linker histones. It can shuttle between the cytoplasm and nucleus, suggesting a role as a histone chaperone. This gene is one of several located near the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. [provided by RefSeq, Jul 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO36473 NAP1L4 Knockout cell line (HeLa) Human NAP1L4 1:3~1:6 Negative Online Inquiry
KO36474 NAP1L4 Knockout cell line (HCT 116) Human NAP1L4 1:2~1:4 Negative Online Inquiry
KO36475 NAP1L4 Knockout cell line (HEK293) Human NAP1L4 1:3~1:6 Negative Online Inquiry
KO36476 NAP1L4 Knockout cell line (A549) Human NAP1L4 1:3~1:4 Negative Online Inquiry

Background

NAP1L4 Gene Knockout Cell Lines represent a novel tool for researchers focusing on the functional characterization of the NAP1L4 gene, which is involved in chromatin remodeling and cellular responses to stress. These genetically engineered cell lines have undergone specific knockout modifications to eliminate the expression of the NAP1L4 gene, allowing for the study of its biological roles and implications in various diseases, including cancer and developmental disorders.

The key functions of the NAP1L4 gene include its contributions to histone assembly and chromatin structure integrity, processes that are crucial for normal cellular function and gene expression. By employing CRISPR-Cas9 technology, these knockout cell lines have been meticulously created to ensure precision and reliability in the absence of NAP1L4, enabling researchers to assess downstream effects on gene expression, cell cycle progression, and responses to DNA damage and repair mechanisms.

The scientific importance of NAP1L4 Gene Knockout Cell Lines cannot be overstated, as they offer valuable insights into the pathophysiological roles of this gene in cellular processes. In clinical research settings, they serve as a platform for drug discovery and testing, particularly in evaluating how targeting the NAP1L4 pathway can affect cellular behavior and treatment responses.

Compared to conventional methods such as RNA interference or transient transfection, our NAP1L4 Gene Knockout Cell Lines provide a stable and sustained model for functional assays, minimizing variability and enhancing reproducibility in experimental outcomes. Researchers benefit from a more streamlined process, facilitating the generation of robust data that can accelerate their investigations.

Ultimately, these cell lines empower researchers and clinicians to unravel the complexities associated with the NAP1L4 gene and its long-standing implications in human health. Our company boasts a strong commitment to advancing genetic engineering technologies, providing high-quality biological products that meet rigorous scientific standards, and supporting cutting-edge research in molecular biology.

Please note that all services are for research use only. Not intended for any clinical use.

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