Gene: NAALAD2
Official Full Name: N-acetylated alpha-linked acidic dipeptidase 2provided by HGNC
Gene Summary: This gene is a member of the N-acetylated alpha-linked acidic dipeptidase (NAALADase) gene family. The representative member of this family is the gene encoding human prostate-specific membrane antigen (PSM), which is a marker of prostatic carcinomas and is the first to be shown to possess NAALADase activity. NAALADase cleaves N-acetyl-L-aspartate-L-glutamate (NAAG), which is a neuropeptide expressed both in the central nervous systems and in the periphery and is thought to function as a neurotransmitter. The product of this gene is a type II integral membrane protein. Transient transfection of this gene confers both NAALADase and dipetidyl peptidase IV activities to mammalian cells. This gene is highly expressed in ovary and testis as well as within discrete brain areas. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO32397 | NAALAD2 Knockout cell line (HCT 116) | Human | NAALAD2 | 1:2~1:4 | Negative | Online Inquiry |
NAALAD2 Gene Knockout Cell Lines are genetically engineered cell models specifically designed to study the function of the N-acetylated alpha-linked acidic dipeptidase 2 (NAALAD2) gene, which encodes a membrane-bound enzyme involved in the hydrolysis of neuropeptides and regulation of neurotransmission. By providing a precise knockout of the NAALAD2 gene, these cell lines enable researchers to investigate the physiological and pathological roles of NAALAD2 in various biological contexts, including neurobiology, cancer, and metabolic disorders.
The mechanism of the NAALAD2 knockout involves targeted gene editing technologies such as CRISPR/Cas9, which ensure high specificity and efficiency in gene disruption. Such modifications allow researchers to elucidate the downstream signaling pathways affected by NAALAD2, as well as its impact on cellular behavior, such as proliferation, differentiation, and apoptosis. This can facilitate a deeper understanding of the role that NAALAD2 plays in neurological diseases, thereby paving the way for potential therapeutic interventions.
The scientific importance of NAALAD2 Gene Knockout Cell Lines lies in their potential applications in both research and clinical settings. These models are invaluable for drug discovery, functional genomics, and studying disease mechanisms, especially in neurodegenerative conditions. Additionally, they serve as a crucial tool for validating hypotheses related to NAALAD2's role in neurotransmission and potential neuroprotective effects.
One of the key advantages of our NAALAD2 Gene Knockout Cell Lines is the precision of the knockout, which ensures that downstream effects can be convincingly attributed to the lack of NAALAD2 expression. This specificity differentiates our product from other models that may exhibit partial or non-specific gene disruption. Furthermore, these cell lines are robust and readily adaptable for high-throughput assays, enhancing their utility in both academic and biopharmaceutical research environments.
Researchers and clinicians pursuing advancements in neuroscience and related fields will find our NAALAD2 Gene Knockout Cell Lines to be an indispensable resource for accelerating their work. These models not only enhance the understanding of complex biological pathways but also contribute to the development of innovative therapies that could improve patient outcomes.
Our company is committed to advancing scientific research through high-quality, customized biological tools, ensuring our clients have access to the best resources available to achieve meaningful breakthroughs in their work.
Please note that all services are for research use only. Not intended for any clinical use.
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