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MYO19 Knockout Cell Lines

Gene: MYO19

Official Full Name: myosin XIXprovided by HGNC

Gene Summary: Enables ATP hydrolysis activity and actin binding activity. Involved in regulation of cytokinesis and regulation of mitochondrial fission. Acts upstream of or within mitochondrion migration along actin filament. Located in cytosol and mitochondrial outer membrane. [provided by Alliance of Genome Resources, Apr 2025]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO00115 MYO19 Knockout cell line (HEK293) Human MYO19 1:3~1:6 Negative Online Inquiry
KO00432 MYO19 Knockout cell line (HeLa) Human MYO19 1:3~1:6 Negative Online Inquiry
KO26174 MYO19 Knockout cell line (HCT 116) Human MYO19 1:2~1:4 Negative Online Inquiry
KO26175 MYO19 Knockout cell line (A549) Human MYO19 1:3~1:4 Negative Online Inquiry

Background

MYO19 Gene Knockout Cell Lines represent a specialized biological tool designed to facilitate the exploration of MYO19 functions within cellular contexts. These cell lines are engineered through CRISPR-Cas9 technology to disrupt the gene encoding for the myosin protein MYO19, which plays crucial roles in mitochondrial dynamics, cytoskeletal organization, and cellular motility. The knockout effectively silences MYO19 expression, enabling researchers to assess the resulting phenotypic alterations and mechanistic pathways influenced by its absence.

The primary function of the MYO19 Gene Knockout Cell Lines centers on the ability to elucidate the biological role of MYO19 in various cellular processes. Researchers can investigate mitochondrial morphogenesis, transport, and bioenergetics under varying conditions, thereby providing insights into the gene’s contribution to cellular health and disease states. This tool is particularly significant in cancer research, neurodegenerative diseases, and studies related to metabolic disorders, as MYO19's interaction with mitochondria may have profound implications for understanding cellular dysfunctions.

Compared to alternative methods of gene silencing such as RNA interference, the MYO19 Gene Knockout Cell Lines offer a permanent and stable knockdown of the target gene, enhancing reproducibility and clarity in experimental outcomes. Furthermore, these optimized cell lines allow for high-throughput screening applications and can be adapted for various mammalian cell types, providing versatility unmatched by traditional knockout methods.

For researchers and clinicians, these cell lines are invaluable, enabling the dissection of complex cellular mechanisms without the variability associated with transient transfection approaches. The use of MYO19 knockout models not only fosters deeper insights into myosin-related cellular functions but also opens avenues for the development of novel therapeutic strategies targeting mitochondrial dysfunctions.

Established in the field of genomic editing and cellular biology, our company is committed to providing high-quality biological models that empower groundbreaking research and clinical innovations. With expertise in generating precise gene-editing tools, we ensure that our MYO19 Gene Knockout Cell Lines embody the rigorous standards required for impactful scientific exploration.

Please note that all services are for research use only. Not intended for any clinical use.

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