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MYH14 Knockout Cell Lines

Gene: MYH14

Official Full Name: myosin heavy chain 14provided by HGNC

Gene Summary: This gene encodes a member of the myosin superfamily. The protein represents a conventional non-muscle myosin; it should not be confused with the unconventional myosin-14 (MYO14). Myosins are actin-dependent motor proteins with diverse functions including regulation of cytokinesis, cell motility, and cell polarity. Mutations in this gene result in one form of autosomal dominant hearing impairment. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO15954 MYH14 Knockout cell line (HCT 116) Human MYH14 1:2~1:4 Negative Online Inquiry
KO15955 MYH14 Knockout cell line (HEK293) Human MYH14 1:3~1:6 Negative Online Inquiry
KO15956 MYH14 Knockout cell line (A549) Human MYH14 1:3~1:4 Negative Online Inquiry

Background

MYH14 Gene Knockout Cell Lines are specialized cell lines engineered to have a complete inactivation of the MYH14 gene, which encodes the myosin heavy chain 14 protein. This product facilitates the comprehensive study of MYH14’s role in various biological processes, including muscle development, cellular motility, and cytoskeletal dynamics. By utilizing CRISPR/Cas9 gene editing technology, these cell lines provide a robust model to elucidate the molecular pathways influenced by MYH14, making them an invaluable tool for genetic research and functional studies in a wide range of applications.

The primary function of the MYH14 Gene Knockout Cell Lines is to allow for the assessment of loss-of-function phenotypes associated with MYH14 deficiencies. Researchers can observe changes in cell morphology, behavior, and proliferation in response to the absence of the MYH14 protein, revealing its potential impact on processes such as muscle contraction and cellular migration. Additionally, these knockout models can significantly contribute to understanding diseases linked to MYH14 dysregulation, including certain types of muscular dystrophies and cancer.

In clinical and research settings, the significance of utilizing MYH14 Gene Knockout Cell Lines lies in their ability to provide insights into the underlying mechanisms of disease and to aid in the development of targeted therapeutic strategies. By characterizing the functional outcomes of MYH14 deletion, scientists can better comprehend its contributions to pathophysiological conditions, thus fostering advancements in precision medicine.

One of the distinct advantages of our MYH14 Gene Knockout Cell Lines over other models is the high efficiency and specificity of gene editing, paired with exceptional reproducibility of results. Unlike traditional knockout models that may carry additional genetic variability, our cell lines offer a well-characterized, uniform system that minimizes confounding factors. This specificity is critical for researchers seeking to achieve high-quality data in their investigations.

As experts in engineered biological products, our company remains committed to providing cutting-edge tools that enhance scientific discovery. Our MYH14 Gene Knockout Cell Lines represent a significant advancement in the field, enabling researchers and clinicians to tackle complex biological questions with precision and confidence.

Please note that all services are for research use only. Not intended for any clinical use.

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