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MYCL Knockout Cell Lines

Gene: MYCL

Official Full Name: MYCL proto-oncogene, bHLH transcription factorprovided by HGNC

Gene Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to act upstream of or within regulation of inner ear auditory receptor cell differentiation. Located in chromosome and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2025]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO02451 MYCL Knockout cell line (HCT 116) Human MYCL 1:2~1:4 Negative Online Inquiry
KO02452 MYCL Knockout cell line (HEK293) Human MYCL 1:3~1:6 Negative Online Inquiry
KO02453 MYCL Knockout cell line (A549) Human MYCL 1:3~1:4 Negative Online Inquiry

Background

MYCL Gene Knockout Cell Lines are genetically engineered cellular models designed to specifically disable the MYCL gene, a critical component often implicated in various cancers, particularly neuroblastoma and other malignancies. These knockout cell lines serve as a powerful tool in molecular biology research and therapeutic development by allowing researchers to elucidate the gene's function and its role in tumorigenesis.

The primary mechanism of action involves the targeted disruption of the MYCL gene through CRISPR-Cas9 or other gene-editing technologies, effectively creating a genetic environment that mimics the natural loss of function observed in pathological conditions. This enables detailed investigations into cellular signaling pathways, metabolic alterations, and gene expression profiles associated with MYCL deficiency. By observing the physiological changes in these cell lines, researchers can gain vital insights into the biological consequences of MYCL gene inactivation.

The scientific importance of MYCL Gene Knockout Cell Lines lies in their diverse applications across cancer research, drug discovery, and personalized medicine. These models facilitate the evaluation of therapeutic candidates aimed at re-establishing normal cellular functions affected by MYCL dysregulation. They also serve as platforms for testing targeted therapies, paving the way for advancements in clinical strategies designed to combat MYCL-dependent tumors.

What sets MYCL Gene Knockout Cell Lines apart from alternative models is their high specificity and reproducibility. Each line is rigorously validated to ensure that the MYCL gene is entirely and consistently knocked out, offering unparalleled reliability in experimental results. Unlike conventional cell lines, these knockout models provide a clearer understanding of the causative relationship between MYCL deficiency and tumorigenesis.

For researchers and clinicians seeking to explore innovative approaches to cancer therapy, MYCL Gene Knockout Cell Lines represent a valuable investment. Their unique capabilities enable the dissection of complex biological pathways, ultimately contributing to the development of more effective treatment regimens. Our company prides itself on producing high-quality, reliable biological products, and our expertise in gene editing ensures that users receive best-in-class models tailored to accelerate their research and clinical outcomes.

Please note that all services are for research use only. Not intended for any clinical use.

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