Home / MXI1 Knockout Cell Lines

MXI1 Knockout Cell Lines

Gene: MXI1

Official Full Name: MAX interactor 1, dimerization proteinprovided by HGNC

Gene Summary: Expression of the c-myc gene, which produces an oncogenic transcription factor, is tightly regulated in normal cells but is frequently deregulated in human cancers. The protein encoded by this gene is a transcriptional repressor thought to negatively regulate MYC function, and is therefore a potential tumor suppressor. This protein inhibits the transcriptional activity of MYC by competing for MAX, another basic helix-loop-helix protein that binds to MYC and is required for its function. Defects in this gene are frequently found in patients with prostate tumors. Three alternatively spliced transcripts encoding different isoforms have been described. Additional alternatively spliced transcripts may exist but the products of these transcripts have not been verified experimentally. [provided by RefSeq, Jul 2008]

Get A Quote
Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO02640 MXI1 Knockout cell line (HeLa) Human MXI1 1:3~1:6 Negative Online Inquiry
KO02641 MXI1 Knockout cell line (HCT 116) Human MXI1 1:2~1:4 Negative Online Inquiry
KO02642 MXI1 Knockout cell line (HEK293) Human MXI1 1:3~1:6 Negative Online Inquiry
KO02643 MXI1 Knockout cell line (A549) Human MXI1 1:3~1:4 Negative Online Inquiry

Background

MXI1 Gene Knockout Cell Lines are genetically modified cellular models characterized by the selective disruption of the MXI1 gene, which encodes a transcriptional repressor known to influence multiple cellular pathways, including growth regulation and differentiation. By employing advanced CRISPR/Cas9 technology, these cell lines facilitate precise gene knockout, allowing researchers to elucidate the functional role of MXI1 in various biological contexts and disease states.

The primary function of the MXI1 Gene Knockout Cell Lines is to provide a controlled environment for studying the downstream effects of MXI1 loss, impacting oncogenesis, cell cycle regulation, and apoptosis. The knockout results in the aberration of signaling pathways that are crucial for cellular proliferation and homeostasis, enabling researchers to investigate the mechanisms whereby dysregulation contributes to oncogenic processes. This understanding is vital not only in basic research but also in potential therapeutic applications, as it may reveal new drug targets or biomarkers for cancer treatment.

The scientific importance of the MXI1 Gene Knockout Cell Lines extends into clinical settings, particularly in the fields of cancer biology, genetics, and therapeutics. These models serve as valuable tools in drug discovery and validation, allowing for the assessment of therapeutic candidates targeting the altered pathways in MXI1-deficient cells.

In comparison to alternative models, such as transient transfection systems or conventional knockout approaches, our MXI1 Cell Lines offer a stable and consistent background that reflects a more physiologically relevant environment, reducing variability in experimental results. Additionally, the knockout is precisely validated, guaranteeing the integrity of experimental outcomes tailored to both academic research and pharmaceutical development.

The value of MXI1 Gene Knockout Cell Lines lies in their ability to empower researchers and clinicians with critical insights into tumor biology and the molecular regulation of cell fate. With our company’s commitment to high-quality genetic engineering and cell line development, we provide expertly crafted tools that facilitate the advancement of scientific knowledge and innovative therapies. Our expertise ensures that these cell lines are developed with the utmost precision, ready to assist you in unlocking new dimensions of research and clinical application.

Please note that all services are for research use only. Not intended for any clinical use.

Get a free quote

If your question is not addressed through these resources, you can fill out the online form below and we will answer your question as soon as possible.

0

There is no product in your cart.