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MUC12 Knockout Cell Lines

Gene: MUC12

Official Full Name: mucin 12, cell surface associatedprovided by HGNC

Gene Summary: This gene encodes an integral membrane glycoprotein that is a member of the mucin family. Mucins are O-glycosylated proteins that play an essential role in forming protective mucous barriers on epithelial surfaces and have been implicated in epithelial renewal and differentiation. These glycoproteins also play a role in intracellular signaling. This protein is expressed on the apical membrane surface of epithelial cells that line the mucosal surfaces of many different tissues including the colon, pancreas, prostate, and uterus. The expression of this gene is downregulated in colorectal cancer tissue. [provided by RefSeq, Apr 2017]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO04217 MUC12 Knockout cell line (HeLa) Human MUC12 1:3~1:6 Negative Online Inquiry
KO04218 MUC12 Knockout cell line (A549) Human MUC12 1:3~1:4 Negative Online Inquiry

Background

MUC12 Gene Knockout Cell Lines are specifically developed cellular models that have undergone precise genetic editing to inactivate the MUC12 gene. This innovative biotechnological tool serves as a significant resource in the field of functional genomics, allowing researchers to study the role of the MUC12 gene in various physiological and pathological processes. By utilizing CRISPR-Cas9 or other gene editing technologies, these cell lines enable systematic investigations into gene function, signaling pathways, and cellular behaviors associated with MUC12 expression.

The primary function of MUC12 Gene Knockout Cell Lines is to facilitate the exploration of the MUC12 protein, a member of the mucin family, known for its importance in cell signaling and interaction with the immune system. By eliminating MUC12 expression, scientists can discern the gene's influence on cellular characteristics such as adhesion, migration, and proliferation, offering insights into diseases where mucins play a critical role, including cancers and inflammatory disorders.

Scientifically, the significance of MUC12 Gene Knockout Cell Lines extends into diverse research arenas, ranging from cancer biology to drug development. In clinical settings, these models can help elucidate the mechanisms underlying therapeutic resistance, thereby informing the design of more effective treatment strategies. Furthermore, they may serve as valuable tools in biomarker discovery, improving our understanding of disease prognosis and drug response.

What sets our MUC12 Gene Knockout Cell Lines apart from similar products on the market is their high fidelity in gene editing, ensuring consistent and reproducible results, and the comprehensive validation of the knockout efficacy, which saves researchers' time and resources. Additionally, our cell lines come with robust technical support, empowering users with optimal guidance throughout their research journey.

In a landscape where precise gene manipulation is fundamental, MUC12 Gene Knockout Cell Lines stand out as indispensable assets for researchers and clinicians alike. With our company's extensive expertise in genetic engineering and a commitment to advancing scientific discovery, we provide high-quality biological products designed to enhance research outcomes and contribute significantly to the understanding of gene function in health and disease.

Please note that all services are for research use only. Not intended for any clinical use.

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