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MTX2 Knockout Cell Lines

Gene: MTX2

Official Full Name: metaxin 2provided by HGNC

Gene Summary: The protein encoded by this gene is highly similar to the metaxin 2 protein from mouse, which has been shown to interact with the mitochondrial membrane protein metaxin 1. Because of this similarity, it is thought that the encoded protein is peripherally associated with the cytosolic face of the outer mitochondrial membrane, and that it is involved in the import of proteins into the mitochondrion. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 7. [provided by RefSeq, Jun 2009]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO00080 MTX2 Knockout cell line (HCT 116) Human MTX2 1:2~1:4 Negative Online Inquiry
KO00091 MTX2 Knockout cell line (HeLa) Human MTX2 1:3~1:6 Negative Online Inquiry
KO31643 MTX2 Knockout cell line (HEK293) Human MTX2 1:3~1:6 Negative Online Inquiry

Background

MTX2 Gene Knockout Cell Lines are genetically engineered cell lines specifically designed to lack the functional MTX2 gene, a critical regulator of various cellular processes including mitochondrial dynamics and cellular stress response. The construction of these knockout cell lines is achieved through precise gene-editing technologies, such as CRISPR-Cas9, which employ targeted nucleases to produce double-strand breaks at specific genomic loci, ultimately leading to disruption and loss of function of the MTX2 gene.

The primary function of MTX2 Gene Knockout Cell Lines lies in their ability to facilitate comprehensive studies on the role of the MTX2 gene in mitochondrial metabolism and its impact on overall cellular health. Researchers can leverage these cell lines to investigate underlying mechanisms of diseases where MTX2 may be implicated, such as metabolic disorders or neurodegenerative diseases. The knockout model serves as an invaluable tool for elucidating the molecular pathways that MTX2 influences, providing insights vital for advancing our understanding of mitochondrial dysfunction.

Scientifically, the MTX2 Gene Knockout Cell Lines hold significant potential in both research and clinical settings. They can be employed in drug discovery processes to identify compounds that restore normal function in cells where the MTX2 gene is inactivated, thus highlighting their utility in therapeutic development. Compared to other models, such as wild-type or overexpression systems, these knockout lines offer a clearer and more specific context for understanding the consequences of gene loss, ultimately leading to more reliable and reproducible results.

The advantages of MTX2 Gene Knockout Cell Lines include precise genomic modifications, consistency in experimental outcomes, and availability of well-characterized lines that facilitate high-throughput screening methods. Furthermore, their application can drive innovations in translational research, paving the way for targeted therapies that address mitochondrial-related conditions.

Our company, with years of experience in developing advanced genetic engineering tools, offers MTX2 Gene Knockout Cell Lines as part of a comprehensive suite of high-quality biological products. We are committed to supporting researchers and clinicians in their quest for groundbreaking discoveries that could revolutionize the understanding and treatment of diverse medical challenges.

Please note that all services are for research use only. Not intended for any clinical use.

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