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MTMR3 Knockout Cell Lines

Gene: MTMR3

Official Full Name: myotubularin related protein 3provided by HGNC

Gene Summary: This gene encodes a member of the myotubularin dual specificity protein phosphatase gene family. The encoded protein is structurally similar to myotubularin but in addition contains a FYVE domain and an N-terminal PH-GRAM domain. The protein can self-associate and also form heteromers with another myotubularin related protein. The protein binds to phosphoinositide lipids through the PH-GRAM domain, and can hydrolyze phosphatidylinositol(3)-phosphate and phosphatidylinositol(3,5)-biphosphate in vitro. The encoded protein has been observed to have a perinuclear, possibly membrane-bound, distribution in cells, but it has also been found free in the cytoplasm. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO07875 MTMR3 Knockout cell line (HeLa) Human MTMR3 1:3~1:6 Negative Online Inquiry
KO07876 MTMR3 Knockout cell line (HCT 116) Human MTMR3 1:2~1:4 Negative Online Inquiry
KO07877 MTMR3 Knockout cell line (HEK293) Human MTMR3 1:3~1:6 Negative Online Inquiry
KO07878 MTMR3 Knockout cell line (A549) Human MTMR3 1:3~1:4 Negative Online Inquiry

Background

MTMR3 Gene Knockout Cell Lines are genetically engineered cell lines specifically designed to lack functional MTMR3 genes, which are integral in the regulation of cellular processes such as autophagy, membrane trafficking, and lipid homeostasis. By elucidating the role of MTMR3, researchers can explore its implications in various physiological and pathological contexts, such as cancer, neurodegeneration, and metabolic disorders.

The primary function of these knockout cell lines is to serve as valuable tools in understanding the molecular mechanisms by which MTMR3 influences cellular functions. The knockout strategy employs CRISPR-Cas9 technology or similar gene-editing techniques, ensuring precise ablation of the gene while maintaining cellular viability. The absence of MTMR3 allows for the analysis of associated signaling pathways, differential gene expression, and changes in cell morphology, confirming its critical role in cellular homeostasis and disease pathways.

The scientific importance of MTMR3 Gene Knockout Cell Lines is underscored by their versatility in both basic research and translational studies. They are pivotal for examining the molecular underpinnings of disorders linked to dysfunctional MTMR3, providing insights that can lead to novel therapeutic targets. In clinical settings, the data obtained from these cell lines can significantly enhance the understanding of genetic factors in diseases, aiding the development of personalized medicine approaches.

Compared to alternative models such as wild-type cell lines or animal models, MTMR3 Gene Knockout Cell Lines offer a more controlled environment for studying the precise effects of MTMR3 deficiency without confounding genetic variables. This specificity facilitates more robust and reproducible results, making these cell lines especially attractive for high-throughput screening applications.

For researchers and clinicians alike, the value of MTMR3 Gene Knockout Cell Lines lies not only in their ability to elucidate complex biological processes but also in their potential to drive innovation in therapeutic strategies. By providing definitive insights into the role of MTMR3, this product supports endeavors in both academia and industry focused on developing new interventions for diseases.

Our company is committed to delivering high-quality biological products, utilizing cutting-edge gene editing technologies to support your research and clinical goals. With a focus on scientific accuracy and innovation, we empower researchers to unlock the complexities of cellular biology and advance the frontiers of medical science.

Please note that all services are for research use only. Not intended for any clinical use.

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