Gene: MTMR14
Official Full Name: myotubularin related protein 14provided by HGNC
Gene Summary: This gene encodes a myotubularin-related protein. The encoded protein is a phosphoinositide phosphatase that specifically dephosphorylates phosphatidylinositol 3,5-biphosphate and phosphatidylinositol 3-phosphate. Mutations in this gene are correlated with autosomal dominant centronuclear myopathy. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 18.[provided by RefSeq, Apr 2010]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO09706 | MTMR14 Knockout cell line (HeLa) | Human | MTMR14 | 1:3~1:6 | Negative | Online Inquiry |
KO09707 | MTMR14 Knockout cell line (HCT 116) | Human | MTMR14 | 1:2~1:4 | Negative | Online Inquiry |
KO09708 | MTMR14 Knockout cell line (HEK293) | Human | MTMR14 | 1:3~1:6 | Negative | Online Inquiry |
KO09709 | MTMR14 Knockout cell line (A549) | Human | MTMR14 | 1:3~1:4 | Negative | Online Inquiry |
MTMR14 Gene Knockout Cell Lines represent a pioneering resource in molecular biology designed to facilitate in-depth studies of the MTMR14 gene, known for its critical role in regulating cellular processes such as autophagy and phosphoinositide metabolism. Generated via advanced CRISPR/Cas9 gene editing techniques, these knockout cell lines exhibit a complete absence of the MTMR14 protein, thereby allowing researchers to investigate the downstream effects of its loss on cellular function, signal transduction pathways, and overall cell health.
The primary function of MTMR14 is to dephosphorylate phosphoinositides, a process vital for maintaining cellular signaling and membrane dynamics. By utilizing these knockout cell lines, scientists can elucidate the molecular mechanisms underpinning diseases associated with MTMR14 dysfunction, such as neurodegenerative disorders and certain forms of cancer. Their application extends beyond basic research; these cell lines can be utilized in drug discovery, screening assays, and translational studies aimed at developing novel therapeutic strategies.
One of the unique advantages of MTMR14 Gene Knockout Cell Lines is the precision and reliability of the CRISPR/Cas9 editing technology used in their development. Unlike traditional methods such as siRNA knockdowns, the knockout status is permanent, enabling long-term studies without variability often seen in transient models. Furthermore, researchers benefit from well-characterized, consistent cell behavior, essential for reproducibility and validation in scientific experiments.
For researchers and clinicians alike, the value of the MTMR14 Gene Knockout Cell Lines lies not only in their contributions to advancing our understanding of molecular biology but also in driving innovation in therapeutic applications. Our commitment to quality and precision in the generation of these models ensures that users receive a reliable source of biological material for their research needs.
As a leader in the field of genetic engineering, our company specializes in providing bespoke biological products tailored to meet the highest standards of research excellence, equipping you with the tools necessary to push the boundaries of current scientific understanding.
Please note that all services are for research use only. Not intended for any clinical use.
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