Gene: MTA1
Official Full Name: metastasis associated 1provided by HGNC
Gene Summary: This gene encodes a protein that was identified in a screen for genes expressed in metastatic cells, specifically, mammary adenocarcinoma cell lines. Expression of this gene has been correlated with the metastatic potential of at least two types of carcinomas although it is also expressed in many normal tissues. The role it plays in metastasis is unclear. It was initially thought to be the 70kD component of a nucleosome remodeling deacetylase complex, NuRD, but it is more likely that this component is a different but very similar protein. These two proteins are so closely related, though, that they share the same types of domains. These domains include two DNA binding domains, a dimerization domain, and a domain commonly found in proteins that methylate DNA. The profile and activity of this gene product suggest that it is involved in regulating transcription and that this may be accomplished by chromatin remodeling. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO33579 | MTA1 Knockout cell line (HeLa) | Human | MTA1 | 1:3~1:6 | Negative | Online Inquiry |
KO33580 | MTA1 Knockout cell line (HCT 116) | Human | MTA1 | 1:2~1:4 | Negative | Online Inquiry |
KO33581 | MTA1 Knockout cell line (HEK293) | Human | MTA1 | 1:3~1:6 | Negative | Online Inquiry |
KO33582 | MTA1 Knockout cell line (A549) | Human | MTA1 | 1:3~1:4 | Negative | Online Inquiry |
MTA1 Gene Knockout Cell Lines are specially engineered cells that have had the MTA1 gene, known for its role in chromatin remodeling and transcriptional regulation, completely disrupted. This strategic modification allows researchers to study the gene's functional contributions to cellular processes, particularly in oncogenesis, stem cell biology, and other developmental pathways. The removal of the MTA1 gene serves as a powerful tool to elucidate its involvement in cancer progression and metastasis, providing insights into pathways that could potentially be targeted for therapeutic intervention.
These knockout cell lines function by providing a controlled environment in which the absence of MTA1 can be assessed. Researchers can utilize various assays, including proliferation, invasion, and migration tests, to determine how the absence of this specific gene influences cell behavior. Moreover, these models enable the study of compensatory mechanisms that might arise in response to gene knockout, further enriching our understanding of cellular networks and signaling pathways involved in disease.
The scientific importance of MTA1 Gene Knockout Cell Lines spans both fundamental research and clinical applications. In cancer research, for example, they can help identify new biomarkers for diagnosis and prognosis by revealing how the deletion of MTA1 affects tumorigenesis. Additionally, these cell lines can serve as platforms for drug discovery, enabling the testing of targeted therapies that exploit vulnerabilities created by the loss of MTA1 function.
One of the notable advantages of MTA1 Gene Knockout Cell Lines over alternative models, such as traditional knockdown strategies or synthetic lethal approaches, lies in their complete gene disruption. This approach eliminates variability stemming from residual gene activity or expression, providing researchers with more definitive insights into gene function. Furthermore, our cell lines are rigorously validated for consistency and reliability, ensuring that they deliver reproducible results across experiments.
For researchers and clinicians invested in understanding the complexities of gene regulation and its implications in health and disease, MTA1 Gene Knockout Cell Lines represent a critical resource. Their application can pave the way for novel therapeutic strategies and enhance our overall understanding of genomic influences on cell behavior. Our company is dedicated to providing high-quality biological products supported by advanced research and development expertise, ensuring that our customers have access to the tools necessary for groundbreaking discoveries in the field of molecular biology and genetics.
Please note that all services are for research use only. Not intended for any clinical use.
If your question is not addressed through these resources, you can fill out the online form below and we will answer your question as soon as possible.
There is no product in your cart. |
CD Biosynsis is a leading customer-focused biotechnology company dedicated to providing high-quality products, comprehensive service packages, and tailored solutions to support and facilitate the applications of synthetic biology in a wide range of areas.