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MSRB3 Knockout Cell Lines

Gene: MSRB3

Official Full Name: methionine sulfoxide reductase B3provided by HGNC

Gene Summary: The protein encoded by this gene catalyzes the reduction of methionine sulfoxide to methionine. This enzyme acts as a monomer and requires zinc as a cofactor. Several transcript variants encoding two different isoforms have been found for this gene. One of the isoforms localizes to mitochondria while the other localizes to endoplasmic reticula. [provided by RefSeq, Jul 2010]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO21206 MSRB3 Knockout cell line (HeLa) Human MSRB3 1:3~1:6 Negative Online Inquiry
KO21207 MSRB3 Knockout cell line (HCT 116) Human MSRB3 1:2~1:4 Negative Online Inquiry
KO21208 MSRB3 Knockout cell line (HEK293) Human MSRB3 1:3~1:6 Negative Online Inquiry
KO21209 MSRB3 Knockout cell line (A549) Human MSRB3 1:3~1:4 Negative Online Inquiry

Background

MSRB3 Gene Knockout Cell Lines are genetically modified cell lines specifically designed to lack the expression of the MSRB3 gene, which encodes for methionine sulfoxide reductase B3, an enzyme involved in cellular defense against oxidative stress. The knockout of this gene allows researchers to investigate the role of MSRB3 in various biological processes and pathologies, particularly those associated with oxidative damage and cellular signaling.

The key function of these cell lines lies in their ability to elucidate the cellular mechanisms by which the absence of MSRB3 influences oxidative stress responses, apoptosis, and signal transduction pathways. By studying these effects, scientists can gain insights into the gene's contribution to diseases such as neurodegeneration, cancer, and metabolic disorders. Additionally, the knockout cell lines serve as vital tools for drug development, enabling researchers to screen potential therapeutic agents targeting oxidative stress pathways.

In terms of scientific importance, MSRB3 Gene Knockout Cell Lines have applications in a variety of research contexts, including basic biological research, preclinical studies, and therapeutic development. These cell lines are particularly valuable in understanding the pathology of oxidative stress-related conditions, thereby guiding the design of novel interventions and treatment modalities.

Compared to alternative models, the MSRB3 knockout lines provide a highly specific and controlled environment to study the effects of MSRB3 deficiency without the confounding variables typically present in in vivo studies. They are also advantageous in high-throughput screening applications due to their consistent performance and reproducibility.

For researchers and clinicians, utilizing MSRB3 Gene Knockout Cell Lines represents a crucial step in advancing knowledge of cellular resilience mechanisms and contributes significantly to the field of oxidative stress research. Our company specializes in producing high-quality genetically engineered cell lines, ensuring that you have access to the most reliable and relevant tools for your research needs.

Please note that all services are for research use only. Not intended for any clinical use.

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