Gene: MRPS16
Official Full Name: mitochondrial ribosomal protein S16provided by HGNC
Gene Summary: Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that belongs to the ribosomal protein S16P family. The encoded protein is one of the most highly conserved ribosomal proteins between mammalian and yeast mitochondria. Three pseudogenes (located at 8q21.3, 20q13.32, 22q12-q13.1) for this gene have been described. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO03081 | MRPS16 Knockout cell line (HeLa) | Human | MRPS16 | 1:3~1:6 | Negative | Online Inquiry |
KO03082 | MRPS16 Knockout cell line (HCT 116) | Human | MRPS16 | 1:2~1:4 | Negative | Online Inquiry |
KO03083 | MRPS16 Knockout cell line (HEK293) | Human | MRPS16 | 1:3~1:6 | Negative | Online Inquiry |
KO03084 | MRPS16 Knockout cell line (A549) | Human | MRPS16 | 1:3~1:4 | Negative | Online Inquiry |
MRPS16 Gene Knockout Cell Lines are genetically modified cellular models specifically engineered to lack the mitochondrial ribosomal protein S16 (MRPS16). This essential component of the mitochondrial ribosome plays a critical role in protein synthesis within mitochondria, contributing to the production of proteins necessary for cellular energy metabolism and overall cellular function. By utilizing these knockout cell lines, researchers can gain valuable insights into the physiological and pathological roles of MRPS16 in various biological processes.
The key function of MRPS16 Gene Knockout Cell Lines lies in their ability to elucidate the impact of MRPS16 deficiency on mitochondrial function, energy production, and cellular homeostasis. The absence of MRPS16 allows for the investigation of mitochondrial translation activity, revealing the consequences of disrupted protein synthesis on metabolic pathways, oxidative stress, and apoptosis. This model is particularly relevant to studies focusing on mitochondrial diseases, metabolic disorders, and age-related declines in cellular function.
In the realm of research and clinical applications, these cell lines have immense scientific importance. They serve as valuable tools for understanding the mechanisms of mitochondrial dysfunction, potentially leading to the development of innovative therapeutic strategies for diseases associated with mitochondrial impairment. By providing a controlled environment to study the effects of MRPS16 knockout, researchers can identify molecular targets and test therapeutic interventions.
One notable advantage of MRPS16 Gene Knockout Cell Lines is their precision and reliability compared to conventional methods of gene manipulation, such as RNA interference or pharmacological inhibition. These knockout lines offer a stable and reproducible model, minimizing off-target effects and allowing for a clearer interpretation of the results. Furthermore, they can be utilized across various cell types, enhancing their versatility in experimental setups.
For researchers and clinicians, these cell lines represent a significant asset in advancing mitochondrial research and developing targeted treatments for mitochondrial-related diseases. The ability to dissect complex biological questions in a model that mirrors human cellular responses is invaluable in accelerating translational research.
At [Your Company Name], we specialize in providing high-quality genetic models tailored to the needs of the scientific community. Our MRPS16 Gene Knockout Cell Lines embody our commitment to supporting cutting-edge research by offering innovative, reliable tools that enhance our understanding of mitochondrial functions and their implications in health and disease.
Please note that all services are for research use only. Not intended for any clinical use.
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