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MRM2 Knockout Cell Lines

Gene: MRM2

Official Full Name: mitochondrial rRNA methyltransferase 2provided by HGNC

Gene Summary: The protein encoded by this gene is a member of the S-adenosylmethionine-binding protein family. It is a nucleolar protein and it may be involved in the processing and modification of rRNA. This gene has been suggested to be involved in cell cycle control and DNA repair. [provided by RefSeq, Jul 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO26897 MRM2 Knockout cell line (HeLa) Human MRM2 1:3~1:6 Negative Online Inquiry
KO26898 MRM2 Knockout cell line (HCT 116) Human MRM2 1:2~1:4 Negative Online Inquiry
KO26899 MRM2 Knockout cell line (HEK293) Human MRM2 1:3~1:6 Negative Online Inquiry
KO26900 MRM2 Knockout cell line (A549) Human MRM2 1:3~1:4 Negative Online Inquiry

Background

MRM2 Gene Knockout Cell Lines are specifically engineered cell lines that have undergone precise genetic modifications to ablate the function of the MRM2 gene, which is vital for mitochondrial RNA modification and mitochondrial function. These knockout models are invaluable tools for researchers aiming to explore the biological roles of the MRM2 gene in various cellular processes, particularly those related to mitochondrial dynamics, energy metabolism, and cellular stress responses.

The primary function of the MRM2 gene involves the modification of mitochondrial tRNA, which is crucial for the accurate translation of mitochondrial proteins. By utilizing these knockout cell lines, researchers can delineate the impact of MRM2 deficiency on mitochondrial translation and overall cellular health. The perturbation caused by the knockout allows for extensive studies into the downstream effects on metabolic pathways and the implications for diseases associated with mitochondrial dysfunction, such as neurodegenerative disorders and metabolic syndromes.

The scientific importance of MRM2 Gene Knockout Cell Lines lies in their application in both basic and applied research settings. They offer researchers a robust model to investigate gene function, regulatory networks, and mitochondrial-related pathology. Furthermore, these cell lines can serve as a platform for testing potential therapeutic strategies aimed at correcting mitochondrial dysfunction.

One of the distinct advantages of our MRM2 Gene Knockout Cell Lines is their robustness, having been validated through multiple assays to ensure consistent performance across various experimental conditions. Unlike alternatives that may involve transient transfection methods, our knockout model provides stable and permanent genetic modification, thus facilitating long-term studies and high-reproducibility of results.

These cell lines are particularly valuable for researchers and clinicians focusing on mitochondrial biology, genetic engineering, and applications in personalized medicine. The potential for drug discovery and therapeutic interventions in mitochondrial diseases is significant, which underscores the demand for such specialized biological products.

Our company, with extensive expertise in genetic engineering and a track record of high-quality biological products, is committed to advancing research and clinical applications. We empower researchers with reliable tools like MRM2 Gene Knockout Cell Lines, making significant contributions to the understanding and treatment of mitochondrial disorders.

Please note that all services are for research use only. Not intended for any clinical use.

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