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MRGBP Knockout Cell Lines

Gene: MRGBP

Official Full Name: MRG domain binding proteinprovided by HGNC

Gene Summary: Involved in positive regulation of double-strand break repair via homologous recombination and regulation of cell cycle. Located in nucleoplasm. Part of NuA4 histone acetyltransferase complex and nucleosome. [provided by Alliance of Genome Resources, Apr 2025]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO20231 MRGBP Knockout cell line (HeLa) Human MRGBP 1:3~1:6 Negative Online Inquiry
KO20232 MRGBP Knockout cell line (HCT 116) Human MRGBP 1:2~1:4 Negative Online Inquiry
KO20233 MRGBP Knockout cell line (HEK293) Human MRGBP 1:3~1:6 Negative Online Inquiry

Background

MRGBP Gene Knockout Cell Lines are sophisticated biological tools designed for the specific elimination of the MRGBP gene in various cellular environments, providing researchers with a novel capability to explore gene function and its associated pathways. These cell lines are engineered using precise CRISPR-Cas9 technology, ensuring high efficiency and specificity in gene editing, thereby allowing for the study of MRGBP’s role in cellular processes such as protein translation, stress response, and disease mechanisms.

The key mechanism underlying the functionality of these knockout cell lines lies in the targeted mutation of the MRGBP gene, which facilitates the examination of changes in cellular behavior and physiological responses. Researchers can observe the impact of MRGBP loss on processes like mRNA stability, ribosome biogenesis, and the modulation of cellular stress responses. This enables a clear delineation of the gene's role in both normal and pathological states, providing invaluable insights into its biological significance.

The scientific importance of MRGBP Gene Knockout Cell Lines is underscored by their wide-ranging applications across fundamental research, drug discovery, and clinical studies. They serve as vital tools for unraveling the complex interactions of MRGBP within various signaling pathways and could contribute to understanding diseases such as cancer and neurodegeneration.

Compared to traditional knockdown methods, these knockout cell lines offer distinct advantages, including permanent gene disruption, enhanced reproducibility, and the potential for temporal studies in long-term experiments. Their unique selling points lie in their ability to generate stable cell lines with validated knockout efficiency, reducing variability and increasing experimental reliability.

This product holds exceptional value for researchers and clinicians alike, offering the opportunity to probe deeply into the functional genomics of MRGBP and its implications in health and disease. With MRGBP Gene Knockout Cell Lines, users can advance their research with confidence, knowing they have access to a precisely engineered and rigorously validated tool.

Our company specializes in the development of cutting-edge biological products that leverage breakthrough technologies to empower researchers in their quest for discovery. We are committed to providing high-quality tools that facilitate groundbreaking research and contribute to the development of innovative therapeutic strategies.

Please note that all services are for research use only. Not intended for any clinical use.

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