Gene: MPZL2
Official Full Name: myelin protein zero like 2provided by HGNC
Gene Summary: Thymus development depends on a complex series of interactions between thymocytes and the stromal component of the organ. Epithelial V-like antigen (EVA) is expressed in thymus epithelium and strongly downregulated by thymocyte developmental progression. This gene is expressed in the thymus and in several epithelial structures early in embryogenesis. It is highly homologous to the myelin protein zero and, in thymus-derived epithelial cell lines, is poorly soluble in nonionic detergents, strongly suggesting an association to the cytoskeleton. Its capacity to mediate cell adhesion through a homophilic interaction and its selective regulation by T cell maturation might imply the participation of EVA in the earliest phases of thymus organogenesis. The protein bears a characteristic V-type domain and two potential N-glycosylation sites in the extracellular domain; a putative serine phosphorylation site for casein kinase 2 is also present in the cytoplasmic tail. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO32156 | MPZL2 Knockout cell line (HeLa) | Human | MPZL2 | 1:3~1:6 | Negative | Online Inquiry |
KO32157 | MPZL2 Knockout cell line (HCT 116) | Human | MPZL2 | 1:2~1:4 | Negative | Online Inquiry |
KO32158 | MPZL2 Knockout cell line (HEK293) | Human | MPZL2 | 1:3~1:6 | Negative | Online Inquiry |
MPZL2 Gene Knockout Cell Lines are specialized cellular models designed to investigate the functional roles of the MPZL2 gene, which encodes for the myelin protein zero-like 2. These engineered cell lines have been generated using advanced genome editing techniques, such as CRISPR-Cas9, enabling the precise deletion of MPZL2, thereby facilitating studies on its contribution to various biological processes, including cell adhesion, signaling pathways, and immune responses.
The primary mechanism of action revolves around the disruption of the MPZL2 protein function, allowing researchers to elucidate the gene's role in relevant physiological and pathological contexts. The absence of this gene provides a unique platform to mimic diseases related to autoimmune responses, cancer, and neurodegenerative conditions, significantly advancing our understanding of these complex mechanisms.
In scientific research and clinical settings, MPZL2 Gene Knockout Cell Lines are invaluable for drug discovery, biomarker identification, and therapeutic development. By providing insights into the gene's function, these cell lines can assist in identifying potential therapeutic targets and enhancing the understanding of disease intersections with immune cell activity.
The unique advantage of using MPZL2 Gene Knockout Cell Lines lies in their specificity and reproducibility. Unlike traditional cell lines that may express multiple genetic variations, these knockout models ensure a consistent genetic background, thereby reducing variability in experimental results. This precision advantage facilitates reliable data generation that is directly translatable to therapeutic advancements.
For researchers and clinicians, the value of leveraging MPZL2 Gene Knockout Cell Lines cannot be overstated. By utilizing these sophisticated models, they can accelerate the translation of basic research into clinical applications and improve therapeutic outcomes for patients.
Our company, a leader in the development of advanced biological tools, is dedicated to providing high-quality gene-edited cell lines tailored to the needs of modern research. Our expertise in molecular genetics and cell biology underpins our commitment to fostering innovation in scientific discovery.
Please note that all services are for research use only. Not intended for any clinical use.
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