Gene: MPP1
Official Full Name: MAGUK p55 scaffold protein 1provided by HGNC
Gene Summary: This gene encodes the prototype of the membrane-associated guanylate kinase (MAGUK) family proteins. MAGUKs interact with the cytoskeleton and regulate cell proliferation, signaling pathways, and intercellular junctions. The encoded protein is an extensively palmitoylated membrane phosphoprotein containing a PDZ domain, a Src homology 3 (SH3) motif, and a guanylate kinase domain. This gene product interacts with various cytoskeletal proteins and cell junctional proteins in different tissue and cell types, and may be involved in the regulation of cell shape, hair cell development, neural patterning of the retina, and apico-basal polarity and tumor suppression pathways in non-erythroid cells. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO03863 | MPP1 Knockout cell line (HeLa) | Human | MPP1 | 1:3~1:6 | Negative | Online Inquiry |
KO03864 | MPP1 Knockout cell line (HCT 116) | Human | MPP1 | 1:2~1:4 | Negative | Online Inquiry |
KO03865 | MPP1 Knockout cell line (HEK293) | Human | MPP1 | 1:3~1:6 | Negative | Online Inquiry |
KO03866 | MPP1 Knockout cell line (A549) | Human | MPP1 | 1:3~1:4 | Negative | Online Inquiry |
MPP1 Gene Knockout Cell Lines are genetically modified cell lines specifically engineered to lack the expression of the MPP1 gene, which encodes for the membrane-associated guanylate kinase family protein. This versatile tool is invaluable for researchers studying the roles of MPP1 in cellular signaling pathways and its implications in various diseases, including cancer and neurological disorders. By enabling the exploration of MPP1's biological functions, these knockout cell lines facilitate a deeper understanding of pathophysiological processes, providing a critical platform for translational research.
The key mechanism underlying the use of MPP1 Gene Knockout Cell Lines involves the precise ablation of the MPP1 gene through advanced gene-editing techniques such as CRISPR/Cas9. This disruptive strategy allows scientists to investigate the gene's contribution to processes such as cell proliferation, apoptosis, and synaptic signaling, thus uncovering potential therapeutic targets. The loss of MPP1 expression can shed light on its roles in tumorigenesis or neurodegenerative disorders, making these cell lines essential for drug development and disease modeling.
From a scientific perspective, MPP1 Gene Knockout Cell Lines represent a significant advancement in the field of functional genomics. Their application spans various research disciplines, including cancer biology, neuroscience, and pharmacology, making them suitable for academic research, drug discovery, and clinical assays. This product offers researchers a unique opportunity to manipulate the MPP1 pathway, paving the way for novel discoveries in cellular mechanisms and therapeutic interventions.
What sets MPP1 Gene Knockout Cell Lines apart from traditional cell lines is their high specificity and reliability in mimicking the genetic landscape of pathological states. Researchers can rely on consistent performance and reproducibility, ensuring that experimental results are robust and scientifically valid. Additionally, these knockout lines support a wide array of downstream applications, including functional assays, high-throughput screening, and co-culture studies.
The value of MPP1 Gene Knockout Cell Lines lies in their potential to accelerate research findings and therapeutic strategies. By understanding MPP1's role in disease, researchers and clinicians can enhance their quest for innovative treatment options. Our company, recognized for its commitment to providing cutting-edge biological products, offers MPP1 Gene Knockout Cell Lines with unparalleled quality and technical support, ensuring that our customers can achieve their research goals efficiently.
Please note that all services are for research use only. Not intended for any clinical use.
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