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MPC1 Knockout Cell Lines

Gene: MPC1

Official Full Name: mitochondrial pyruvate carrier 1provided by HGNC

Gene Summary: The protein encoded by this gene is part of an MPC1/MPC2 heterodimer that is responsible for transporting pyruvate into mitochondria. The encoded protein is found in the inner mitochondrial membrane. Defects in this gene are a cause of mitochondrial pyruvate carrier deficiency. Several transcript variants, some protein coding and one non-protein coding, have been found for this gene. [provided by RefSeq, Aug 2012]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO22309 MPC1 Knockout cell line (HeLa) Human MPC1 1:3~1:6 Negative Online Inquiry
KO22310 MPC1 Knockout cell line (HCT 116) Human MPC1 1:2~1:4 Negative Online Inquiry
KO22311 MPC1 Knockout cell line (HEK293) Human MPC1 1:3~1:6 Negative Online Inquiry
KO22312 MPC1 Knockout cell line (A549) Human MPC1 1:3~1:4 Negative Online Inquiry

Background

MPC1 Gene Knockout Cell Lines are specialized cellular models engineered to facilitate the study of the MPC1 gene's functions and its role in metabolic pathways. These cell lines have been generated through targeted gene editing techniques, such as CRISPR/Cas9, resulting in the loss of MPC1 expression. This knockout mechanism allows researchers to observe the downstream effects of MPC1 disruption on cellular metabolism, mitochondrial function, and integration of cellular energy regulation.

The key function of MPC1 is its involvement in mitochondrial pyruvate transport—an essential step in cellular energy production. By utilizing these knockout cell lines, scientists can elucidate the implications of impaired pyruvate transport on cellular respiration and associated metabolic disorders. The loss-of-function studies performed using these cell lines are critical for understanding various diseases linked to metabolic dysregulation, including diabetes and cancer.

The scientific importance of the MPC1 Gene Knockout Cell Lines extends beyond basic research; they hold potential applications in translational medicine. Understanding the regulatory mechanisms involving MPC1 may lead to novel therapeutic strategies targeting metabolic pathways in various clinical settings.

Compared to alternative models, these knockout cell lines provide a more precise and reliable platform for investigating specific genetic contributions to metabolic processes, ensuring that research outcomes are highly relevant and reproducible. Their use minimizes confounding variables often seen in wild-type models.

For researchers and clinicians focused on unraveling the complexities of mitochondrial biology or developing interventions for metabolic diseases, these cell lines represent a valuable resource. They bolster the capability to accelerate discoveries that could transform treatment paradigms in health and disease management.

Our company prides itself on its commitment to advancing research tools and technologies, ensuring researchers have access to high-quality, innovative products like the MPC1 Gene Knockout Cell Lines that empower scientific inquiry and facilitate breakthroughs in understanding human health.

Please note that all services are for research use only. Not intended for any clinical use.

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