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MMP7 Knockout Cell Lines

Gene: MMP7

Official Full Name: matrix metallopeptidase 7provided by HGNC

Gene Summary: This gene encodes a member of the peptidase M10 family of matrix metalloproteinases (MMPs). Proteins in this family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. The encoded preproprotein is proteolytically processed to generate the mature protease. This secreted protease breaks down proteoglycans, fibronectin, elastin and casein and differs from most MMP family members in that it lacks a conserved C-terminal hemopexin domain. The enzyme is involved in wound healing, and studies in mice suggest that it regulates the activity of defensins in intestinal mucosa. The gene is part of a cluster of MMP genes on chromosome 11. This gene exhibits elevated expression levels in multiple human cancers. [provided by RefSeq, Jan 2016]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO11734 MMP7 Knockout cell line (HCT 116) Human MMP7 1:2~1:4 Negative Online Inquiry
KO11735 MMP7 Knockout cell line (A549) Human MMP7 1:3~1:4 Negative Online Inquiry

Background

MMP7 Gene Knockout Cell Lines represent a specialized tool developed for studying the role of the matrix metalloproteinase 7 (MMP7) gene in various biological processes and diseases. MMP7 is critical for extracellular matrix remodeling, inflammation, and tissue repair. By utilizing gene knockout technology, these cell lines allow researchers to investigate the functions of MMP7 in cellular contexts where it is absent, enabling insights into its contribution to pathogenic processes, such as cancer metastasis, fibrosis, and autoimmune disorders.

The key function of MMP7 Gene Knockout Cell Lines rests on the fundamental mechanism of gene disruption achieved through CRISPR-Cas9 technology or similar gene-editing approaches. This knockout creates a model in which researchers can assess phenotypic changes, cellular behavior, and molecular signaling pathways in the absence of MMP7, thereby elucidating its specific roles in physiological and pathological settings. Such models are essential for understanding how the loss of MMP7 affects cellular processes, supporting the development of targeted therapies and strategic interventions.

In both research and clinical settings, MMP7 Gene Knockout Cell Lines hold significant importance. They serve as platforms for drug discovery, screening potential therapeutic agents that may modulate MMP7 activity, and for investigating the biomolecular underpinnings of diseases. This functional analysis can lead to breakthroughs in diagnostics and tailored treatment plans.

The unique selling points of MMP7 Gene Knockout Cell Lines include their specificity and reliability. Unlike alternative cell lines that may retain some residual activity of the target gene, our knockout models ensure complete removal of MMP7 function, providing definitive insights into its roles. Furthermore, our lines are validated for consistent performance, ensuring reproducibility and accuracy in experimental results.

Researchers and clinicians benefit immensely from the availability of these knockout cell lines, as they enable precise investigations into MMP7's biological significance. The ability to produce robust, high-quality data supports the advancement of research in critical areas, making MMP7 Gene Knockout Cell Lines a valuable addition to any laboratory focused on molecular biology, cancer research, or drug development.

At [Your Company Name], we pride ourselves on our commitment to delivering innovative, high-quality biological tools that empower scientific advancement. Our expertise in cell line development and gene editing positions us as a leader in providing researchers with the resources necessary to push the boundaries of discovery.

Please note that all services are for research use only. Not intended for any clinical use.

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