Gene: MMP25
Official Full Name: matrix metallopeptidase 25provided by HGNC
Gene Summary: Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMPs are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the protein encoded by this gene is a member of the membrane-type MMP (MT-MMP) subfamily, attached to the plasma membrane via a glycosylphosphatidyl inositol anchor. In response to bacterial infection or inflammation, the encoded protein is thought to inactivate alpha-1 proteinase inhibitor, a major tissue protectant against proteolytic enzymes released by activated neutrophils, facilitating the transendothelial migration of neutrophils to inflammatory sites. The encoded protein may also play a role in tumor invasion and metastasis through activation of MMP2. The gene has previously been referred to as MMP20 but has been renamed MMP25. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO16139 | MMP25 Knockout cell line (HCT 116) | Human | MMP25 | 1:2~1:4 | Negative | Online Inquiry |
MMP25 Gene Knockout Cell Lines are genetically modified cell lines specifically designed to lack the expression of the matrix metalloproteinase 25 (MMP25) gene. MMPs are a pivotal group of enzymes responsible for the degradation of extracellular matrix components, often playing critical roles in tissue remodeling, wound healing, and various pathological processes, such as cancer metastasis and inflammatory diseases. By using these knockout cell lines, researchers can gain insights into the function of MMP25 and its contributions to these biological processes, allowing them to elucidate its role in disease progression and potential therapeutic targeting.
The primary function of the MMP25 knockout cell lines lies in their ability to serve as a controlled model system for studying the cellular and molecular consequences of MMP25 deficiency. Researchers can investigate how the absence of this enzyme affects various cellular behaviors, such as proliferation, migration, and invasion, under different experimental conditions. By comparing gene expression profiles, proteomic changes, and cellular phenotypes between MMP25 knockout lines and wild-type controls, scientists can obtain valuable information about the mechanistic pathways influenced by MMP25.
The scientific importance of MMP25 knockouts is particularly relevant in cancer research, where they can be used to explore how MMP25 contributes to tumor microenvironments, metastasis, and the response to pharmacological treatments. Beyond oncology, these cell lines are applicable in studies of fibrosis and inflammatory disorders, making them a versatile tool for academic and clinical research settings.
One of the key advantages of our MMP25 Gene Knockout Cell Lines is their precision and reliability. Our cell lines undergo rigorous validation to ensure a consistent knockout of the MMP25 gene, which is essential for reproducible research outcomes. Furthermore, unlike alternative models that may present background expression or off-target effects, our knockout cell lines provide a definitive platform for studying the unique role of MMP25 in diverse biological contexts.
For researchers and clinicians seeking to deepen their understanding of MMP25, these knockout cell lines present an unmatched opportunity to dissect complex pathophysiological processes and explore potential therapeutic interventions. With our commitment to quality and innovation, we leverage cutting-edge technologies and a dedicated scientific team to provide high-quality biological products that facilitate groundbreaking research.
Please note that all services are for research use only. Not intended for any clinical use.
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